血骨质红素反映了急性胰腺炎中的组织损伤
Lina Wirestam1, Pernilla Benjaminsson Nyberg2,3, Todor Dzhendov2,3
1Department of Biomedical and Clinical Sciences, Division of Inflammation & Infection, Linköping University, SE-581 85 Linköping, Sweden.
Biomedicines
|June 28, 2023
概括
奥斯托邦丁 (OPN) 显示为急性胰腺炎 (AP) 的生物标志物具有前途. 虽然初始水平不能预测严重程度,但随着时间的推移,变化可能有助于早期识别有风险的患者.
科学领域:
- 生物化学 生物化学
- 临床医学 临床医学
- 生物标志物发现发现
背景情况:
- 急性胰腺炎 (AP) 严重程度的临床预测依赖于评分系统,但需要一个简单的生物标志物.
- 骨质松 (OPN) 涉及组织损伤,但其在AP严重性方面的作用尚不清楚.
研究的目的:
- 评估与急性胰腺炎 (AP) 严重程度相关的血骨质素 (OPN) 水平.
- 确定OPN是否可以作为AP的早期,易于测量的生物标志物.
主要方法:
- 在三天内从39名AP患者和39名健康对照组收集了血.
- 使用商业酶链免疫吸收试验 (ELISA) 测量血OPN.
- 在轻度和中度至重度的AP组之间,在入院时和随着时间的推移中比较的OPN水平.
主要成果:
- AP患者的入院OPN水平明显高于对照组 (156.4 ng/mL与37.4 ng/mL相比,p < 0.0001).
- 入院OPN水平没有区分轻度和中度至重度的AP.
- 在中度至重度的AP中,与轻度的AP相比,在24小时和第2/3天的OPN显著增加 (33.7%vs. -8.1%,p = 0.01).
结论:
- 骨质疏松素 (OPN) 是一种反映急性胰腺炎 (AP) 组织损伤的相关生物标志物.
- 序列OPN测量可能有助于早期检测具有更高风险的AP患者.
- 需要进一步的前性研究来确认OPN在AP结果中的预后价值.
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