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在过度活跃膀的女性中异常休息状态网络存在
Ulrich Mehnert1, Matthias Walter1,2, Lorenz Leitner1
1Department of Neuro-Urology, Balgrist University Hospital, University of Zürich, 8008 Zürich, Switzerland.
Biomedicines
|June 28, 2023
概括
过度活跃的膀 (OAB) 与大脑连接的改变有关. 这项研究发现OAB患者和健康个体之间的大脑网络存在显著差异,这表明未来治疗的脊上点.
科学领域:
- 神经科学是一个神经科学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 医疗成像医学成像
背景情况:
- 过活性膀 (OAB) 在全球范围内显著影响患者的生活质量和医疗保健成本.
- 目前尚不完全了解OAB的根本原因,但可能涉及到脊上神经网络的变化.
研究的目的:
- 在患有过度活性膀 (OAB) 的患者中研究和描述脊柱上网络的静止状态功能连接.
- 探索OAB中上连接性改变和下泌尿道症状的严重程度之间的关系.
主要方法:
- 利用独立组件分析 (ICA) 和兴趣区域 (ROI) 分析来比较功能性大脑连接.
- 在12名OAB患者和12名60岁以下的健康对照 (HC) 中检查了静止状态功能连接.
- 分析了涉及胰岛和腹侧前额叶皮层的种子-声细胞连接.
主要成果:
- 与HC相比,OAB患者表现出较弱的突出和默认模式网络 (Cohen的d分别为0.9和1.1).
- 在OAB患者中,观察到前额-双肩和突出网络之间的定向连接性减少.
- 在OAB患者中,在前额和前额皮层内,以及在特定的种子区域和口腔之间发现了显著的连接性减少 (科恩d>1.6或<-1.6和>1.9).
结论:
- 在OAB患者中显而易见的超脊柱功能连接性改变与症状严重程度相关.
- 这些发现表明,在未来的OAB治疗策略中,应该考虑上脊柱的目标.
- 神经成像技术可以提高OAB的表型和理解.
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