在肺癌中进行放射治疗和免疫治疗
Kristin Hsieh1, Daniel R Dickstein1, Juliana Runnels1
1Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Biomedicines
|June 28, 2023
概括
免疫检查点抑制剂 (ICI) 与放射治疗相结合,在肺癌治疗中表现有前途. 本综述详细介绍了它们对小细胞和非小细胞肺癌的协同作用和临床应用.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 辐射瘤学 辐射瘤学
背景情况:
- 免疫检查点抑制剂 (ICI) 在癌症治疗中至关重要,突出显示了免疫系统在瘤监测中的作用.
- ICI越来越多地被整合到不同阶段和组织学的肺癌治疗方案中.
- 放射治疗与免疫疗法的作用是肺癌管理的一个不断发展的领域.
研究的目的:
- 提供免疫疗法和放射治疗在肺癌中的整合的全面概述.
- 概述目前和新兴的免疫疗法与放射治疗用于小细胞肺癌 (SCLC) 和非小细胞肺癌 (NSCLC) 的应用.
- 审查那些塑造了护理标准的关键临床试验.
主要方法:
- 这是一个叙事评论.
- 文献搜索的重点是免疫疗法,放射疗法和肺癌治疗.
- 关键的临床试验和实践改变研究被选中进行讨论.
主要成果:
- 同时进行化学放射治疗,然后进行巩固性杜瓦卢马布治疗是国家综合癌症网络推的肺癌治疗方案.
- 其他涉及ICI与化疗和/或手术的治疗范式也得到认可.
- 该审查综合了结合这些模式的协同效应的证据.
结论:
- 免疫治疗和放射治疗的结合在治疗肺癌方面提供了协同效益.
- 证据支持在SCLC和NSCLC中使用这些结合方法.
- 目前正在进行的研究和临床试验继续完善肺癌的治疗策略.
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