优发性双极性患者的语言网络连接在休息时和口语流利任务期间发生变化
Zaira Romeo1, Marco Marino1,2, Dante Mantini2
1Department of General Psychology, University of Padova, 35131 Padova, Italy.
Biomedicines
|June 28, 2023
概括
双极性障碍患者表现出语言网络连接的改变,在休息和口头任务期间,左脑主导性降低. 这表明语言侧面化受损可能是精神病障碍的标志物.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 语言网络 (LN) 的异常在精神疾病中观察到,如精神分裂症和双相情感障碍 (BD).
- 在休息状态下改变的LN不对称性已被记录在BD患者身上.
- 在主动语言任务中LN变化的稳定性仍未得到充分研究.
研究的目的:
- 在休息状态和口头流利性任务期间,研究语言网络 (LN) 的结构和稳定性.
- 在不同的任务条件下,比较BD患者和健康对照 (HC) 之间的LN功能连接.
主要方法:
- 功能性磁共振成像 (fMRI) 数据从16名euthymic BD患者和16名匹配的HC患者中收集.
- 参与者接受了开放眼睛的静止状态扫描和沉默的口语流性任务.
- 空间独立组件分析 (ICA) 用于计算LN功能连接,然后进行组比较.
主要成果:
- 在BD患者中的LN在休息和口头任务期间涉及左脑和右脑区域.
- 与HC的左侧化LN相比,BD患者在口语流利性任务中表现出较低的侧向化与前部集群以及后部语言区域的脱离.
- 在BD患者中,改变的LN连接性在休息状态和活跃语言状态之间是一致的.
结论:
- 减少语言横向化可能作为精神病障碍谱中共享的生物标记.
- 在双相情感障碍中休息时观察到的语言网络连接受损是稳定的,并在活跃的语言处理过程中持续存在.
- 这些发现凸显了双相情感障碍对支持语言的神经系统的普遍影响.
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