MR-proADM作为COVID-19患者预后结果的预后因素
Paolo Cameli1, Elena Pordon1, Miriana d'Alessandro1
1Respiratory Diseases Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, 53100 Siena, Italy.
Biomedicines
|June 28, 2023
概括
血清中区域性腺素 (MR-proADM) 有效预测住院COVID-19患者的死亡率和呼吸支持需求. 将MR-proADM与KL-6和IL-6相结合,进一步提高预后准确性,从而改善患者风险分层.
科学领域:
- 生物化学 生物化学
- 临床医学 临床医学
- 临界护理医学 临界护理医学
背景情况:
- 血清中区域性腺素 (MR-proADM) 是器官衰竭和重症监护室预后不佳的标志物.
- MR-proADM,KL-6和IL-6正在作为COVID-19的潜在预后生物标志物进行研究.
研究的目的:
- 评估MR-proADM在预测住院死亡率方面的表现.
- 评估MR-proADM在住院COVID-19患者中预测需要呼吸支持的能力.
主要方法:
- 74名住院COVID-19患者的回顾性分析.
- 血清样本分析MR-proADM,KL-6和IL-6在入院和1-3天.
- 收集人口统计,临床和结果数据,包括死亡率和重症监护室 (ICU) 入院情况.
主要成果:
- 不幸存者和需要呼吸辅助的患者在入院和第一天显示了较高的MR-proADM水平.
- 第1天的MR-proADM在预测死亡和/或ICU入院方面表现出高准确度 (AUC=0.9583).
- 结合MR-proADM,KL-6和IL-6可以提高预测准确度 (AUC=0.9793).
结论:
- 血清MR-proADM是住院COVID-19患者的可靠预后生物标志物.
- MR-proADM,KL-6和IL-6有助于管理和分层住院患者的风险.
- 这些生物标志物是微创性收集,快速分析,并且具有成本效益.
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