在老鼠中,全粒和精制的谷物通过调节骨质保护素和核因子卡帕B的受体激活剂降低骨矿物质密度和含量
Hussein Sakr1, Zenat Khired2, Marzieh Moghadas1
1Department of Physiology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat 123, Oman.
Biomedicines
|June 28, 2023
概括
在老鼠中,纯全谷物或精制谷物饮食导致骨矿物质密度和含量减少. 这种以谷物为重的饮食也改变了骨循环标记,表明对骨健康的潜在负面影响.
科学领域:
- 营养科学 营养科学
- 骨生物学 骨生物学 骨生物学
- 动物模型 动物模型
背景情况:
- 小麦是全球的主要食品,也是动物料的常见组成部分.
- 饮食对骨健康的影响对于理解骨完整性至关重要.
- 骨周转标记器提供了对骨重塑过程的洞察力.
研究的目的:
- 研究完整和精制小麦谷物饮食对大鼠骨周转标记物的影响.
- 评估无谷物饮食对骨矿物质含量 (BMC) 和骨矿物质密度 (BMD) 的影响.
主要方法:
- 三十只雄性大鼠被分为三个组:对照组 (食),全谷物和精制谷物.
- 骨矿物质含量 (BMC) 和骨矿物质密度 (BMD) 在12周后在骨中被测量.
- 分析了包括TRAP-5b,NTx,DPD,ALP,骨素 (OC),RANK和OPG在内的骨循环标记物的血液水平.
主要成果:
- 与对照组相比,只食用全粒或精制谷物养的老鼠表现出明显较低的BMC和BMD.
- 谷物养的老鼠显示骨质保护素 (OPG),骨质素 (OC) 和性酸酶 (ALP) 的水平降低.
- 在谷物养小组中观察到高水平的RANK,脱氧氨酸 (DPD),酸耐酸酸酶5b (TRAP-5b) 和I型原的N-telopeptide (NTx).
结论:
- 完全或精制小麦粒的饮食对大鼠模型的骨质和骨密度产生了负面影响.
- 无谷物饮食显著改变关键的骨循环标志物,表明发生了代谢转变.
- 这些发现突出了与缺乏多样性的饮食相关的潜在风险,这对骨健康有益.
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