相关实验视频
Updated: Jul 25, 2025

07:09
The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
Published on: July 16, 2014
48.3K
手管道综合征:神经病痛与诺基普拉斯状况相关或不相关
César Fernández-de-Las-Peñas1,2, Stella Fuensalida-Novo1, Jo Nijs3,4,5
1Department of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine, Universidad Rey Juan Carlos, 28922 Alcorcón, Spain.
Biomedicines
|June 28, 2023
概括
管综合征 (CTS) 可能不仅仅是神经疼痛. 这篇论文建议将CTS疼痛分为感觉性,神经病变性或可感性类型,以获得更好的治疗结果.
科学领域:
- 疼痛研究 疼痛研究
- 神经学 神经学
- 精准医学是一门精准的医学.
背景情况:
- 管综合征 (CTS) 传统上被视为一种神经病症.
- 精准医学旨在根据个体患者的个人资料量身定制治疗.
- 国际疼痛研究协会 (IASP) 在2021年推出了表型分级系统.
研究的目的:
- 探索将手足道综合征 (CTS) 疼痛分组为不同的表型的可能性:感觉性,神经性,可塑性或混合.
- 为确定CTS患者中占主导地位的疼痛表型提供框架.
- 通过调整干预措施与特定的疼痛机制来提高治疗效率.
主要方法:
- 审查与CTS疼痛相关的现有数据和临床观察.
- 对疼痛表型的2021年IASP分类标准的应用.
- 开发一种临床决策树,以协助表型识别.
主要成果:
- 带道综合征 (CTS) 可能伴随着并发性诺基普拉斯痛病,而不仅仅是神经病变.
- 超中位症状和促进疼痛处理表明,在某些CTS病例中,存在着nociplastic表型.
- 确定主导的疼痛表型至关重要,因为nociplastic或混合类型可能解释治疗耐药性.
结论:
- 一个显著的手掌道综合征 (CTS) 患者的子集可能会表现出nociplastic或混合疼痛表型.
- 拟议的临床决策树可以帮助使用IASP标准识别这些表型.
- 识别一个nociplastic组件需要一种多模式的治疗方法,以改善CTS管理中的临床结果.
相关概念视频
Nociception
28.0K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
28.0K
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
19
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
19
Local Anesthetics: Differential Sensitivity of Nerve Fibers
878
Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
878
Pain
515
Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
515
Spinal Nerves: Plexus I
1.1K
Nerve plexuses are networks of interlacing nerves that serve as communication hubs to distribute and organize nerve action across various body regions. The nerve plexuses are organized into the cervical plexus located in the neck region, brachial plexus in the shoulder area, lumbar plexus found in the lower back, sacral plexus situated in the pelvis, and coccygeal plexus located in the coccygeal region.
The Cervical Plexus
The cervical plexus, formed by the anterior rami of the first four...
The Cervical Plexus
The cervical plexus, formed by the anterior rami of the first four...
1.1K
Disorders of the Autonomic Nervous System
720
The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
Raynaud's disease, also known as Raynaud's...
720

