低密度脂蛋白胆固醇和血管生物标志物在初级预防中的关联
Michaela Kozakova1,2, Carmela Morizzo3, Giuli Jamagidze4
1Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
Biomedicines
|June 28, 2023
概括
低密度脂蛋白胆固醇 (LDL-C) 与中等风险个体的冠状动脉化 (CAC) 和常见的股骨动脉内膜介质厚度 (IMT) 有关. CAC评分有效指导降脂治疗决策.
科学领域:
- 心血管医学 心血管医学
- 生物标志物 生物标志物
- 预防性心脏病学 预防性心脏病学
背景情况:
- 非侵入性血管生物标志物有助于对动脉血事件的风险分层.
- 鉴定中等风险个体的生物标志物对于优化初级预防中降脂治疗至关重要.
研究的目的:
- 评估血LDL胆固醇与无症状,中等风险个体中的各种血管生物标志物之间的关联.
- 确定血管生物标志物的实用性,以指导降脂治疗决策.
主要方法:
- 这项研究涉及260名无症状的中等心血管风险个体,不包括患有糖尿病或接受降脂治疗的人.
- 血LDL胆固醇与冠状动脉化 (CAC) 阿加斯顿分数,大脑动脉和大腿骨内膜介质厚度 (IMT),大脑动脉延展性和大脑动脉-大腿骨脉冲波速度相关.
- 高/低生物标志物值被定义为高于第95个百分点或低于第5个百分点.
主要成果:
- LDL胆固醇独立地与CAC得分 = 0 (OR 0.67) 和CAC得分> 100 (OR 1.59) 相关.
- 此外,LDL胆固醇还与高常见股骨动脉 (CFA) IMT (OR 1.89) 有关.
- 在LDL胆固醇与其他测试的血管生物标志物之间没有发现显著的关联.
结论:
- 一个CAC分数为0表明可以避免降脂治疗中等风险的个体.
- 一个CAC评分>100表明需要降脂治疗.
- CFA IMT可能是治疗决策的有价值生物标志物,但需要性别和年龄特定的参考值.
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