维生素D:性别医学可以发挥作用吗?
Tiziana Ciarambino1, Pietro Crispino2, Giovanni Minervini3
1Internal Medicine Department, Hospital of Marcianise, ASL Caserta, 81037 Caserta, Italy.
Biomedicines
|June 28, 2023
概括
维生素D缺乏是常见的,但生物可用性,而不仅仅是水平,影响其功能. 性别差异和荷尔蒙变化显著影响维生素D.
科学领域:
- 内分泌学 在内分泌学.
- 营养科学 营养科学
- 分子生物学分子生物学
背景情况:
- 维生素D缺乏是一个全球性的健康问题,血25-氧维生素D水平作为主要指标.
- 维生素D在各种病理机制中的作用是公认的,但它的生物功能是复杂的.
- 目前的理解可能会过分简化维生素D的影响,仅关注摄入量和循环水平.
研究的目的:
- 探索性别差异对维生素D生物和分子功能的影响.
- 调查假设维生素D的生物可用性,而不仅仅是血度,对其功能至关重要.
- 检查女性的荷尔蒙波动和生理状态如何影响维生素D状态和生物可用性.
主要方法:
- 这是一篇叙事性综述,综合了有关维生素D代谢和功能的现有研究.
- 对检查维生素D水平和与性别和荷尔蒙状况相关的生物可用性研究的分析.
- 关于影响维生素D结合蛋白 (DBP) 和专结合的因素的文献综述.
主要成果:
- 维生素D的生物可用性受到白蛋白和DBP等结合蛋白的影响,这些蛋白质由激素 (例如雌激素) 和细胞因子调节.
- 妇女在一生中经历了显著的荷尔蒙变化 (月经,怀孕,更年期),影响维生素D的需求和状态.
- 在年轻女性中报告的维生素D缺乏的高患病率 (58-91%),与肥胖和影响生物可用性的雌激素变异有关.
结论:
- 维生素D的生物功能与其生物可用性密切相关,受结合蛋白和荷尔蒙环境的影响.
- 性别特定的生理变化,特别是在女性身上,为维持适当的维生素D状态创造了独特的挑战.
- 需要进一步的研究,以了解性别,激素和维生素D生物可用性在健康和疾病中的复杂相互作用.
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