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食黄素通过抑制老年小鼠的MAPK/NF-κB信号通路来减轻肝细胞衰老

Da-Yeon Lee¹, Su-Jeong Lee¹, Prabha Chandrasekaran²

¹Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK 74078, USA.

Antioxidants (Basel, Switzerland)

|June 28, 2023

概括

食黄素 (CUR) 补充剂抑制了老年小鼠的肝细胞衰老和炎症. 这种营养策略改善了抗氧化能力和胰岛素平衡,这表明CUR可以预防与年龄相关的肝损伤.

科学领域:

老年学是一门学科.
营养生物化学营养生物化学
肝病学肝病学是一种肝病学.

背景情况:

细胞衰老有助于衰老和与年龄相关的疾病.
生物活性化合物,如黄素 (CUR),显示出缓解衰老的潜力.
CUR在预防肝细胞衰老中的作用需要进一步研究.

研究的目的:

为了研究饮食CUR对老年小鼠肝细胞衰老的影响.
为了确定CUR的抗氧化特性是否可以防止肝脏衰老.
评估CUR对老化相关分泌表型 (SASP) 和相关信号通路的影响.

主要方法:

年老的小鼠接受了饮食中的CUR补充剂.
使用转录基因查分析肝脏基因表达.
评估了包括MAPK,JNK,p38和NF-κB在内的关键信号通路.
测量了炎症的生物标志物,SASP,体重和胰岛素平衡.

主要成果:

补充CUR降低了肝脏中老化相关基因表达的调节.
CUR增强了肝脏的抗氧化特性,并抑制了MAPK信号传递 (JNK和p38).
饮食CUR减少了NF-κB酸化,促炎性细胞因子mRNA和SASP表达.
在老年小鼠中,使用CUR改善了胰岛素平衡,并降低了体重.

结论:

食库尔库作为抗氧化剂,可以抑制肝细胞衰老.
通过抑制MAPK/NF-κB信号传递和减少炎症,CUR减轻了肝脏的衰老.
黄素补充剂代表了一种有前途的营养策略,用于预防与年龄相关的肝细胞衰老.

关键词:

这就是MAPKK的意思.在 NF-κBB 中.细胞衰老细胞衰老库尔库明是一种黄素.肝脏肝脏肝脏肝脏肝脏肝脏一个老年化的老年主义者.

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