用多来准氧化应激以对抗肝脏疾病
Ivo F Machado1,2, Raul G Miranda3, Daniel J Dorta4
1CNC-Center for Neuroscience and Cell Biology, CIBB-Center for Innovative Biomedicine and Biotechnology, University of Coimbra, 3000 Coimbra, Portugal.
Antioxidants (Basel, Switzerland)
|June 28, 2023
概括
素,白醇和黄素等多醇可以减轻肝脏疾病中的氧化损伤. 这些化合物有助于控制活性氧物种 (ROS) 水平,为肝脏病理提供治疗策略.
科学领域:
- 生物化学 生化学
- 细胞生物学 细胞生物学
- 肝病学 肝病学是一种肝病学.
背景情况:
- 反应性氧物种 (ROS) 在细胞代谢和信号传递中起到关键的第二信使作用.
- 在ROS生产和抗氧化能力之间的不平衡导致氧化应激,损害细胞组件和损害功能.
- 氧化应激与肝脏疾病的发病有关,包括缺血 - 反损伤 (LIRI),非酒精性脂肪肝疾病 (NAFLD) 和肝细胞癌 (HCC).
研究的目的:
- 通过检查它们在调节ROS水平中的作用来审查多对肝损伤的治疗作用.
- 总结特定多 (素,白醇,黄素) 对LIRI,NAFLD和HCC模型中氧化损伤的影响.
主要方法:
- 文献综述侧重于研究在肝损伤模型中研究聚醇介导ROS调节的研究.
- 在LIRI,NAFLD和HCC的背景下,分析关于奎尔素,白醇和黄素对氧化应激的保护机制的研究.
主要成果:
- 聚醇在调节ROS水平和减轻氧化损伤方面具有显著的潜力,在各种肝损伤情况下.
- 在临床前和临床研究中,包括素,白醇和黄素在内的特定多醇在治疗与氧化应激相关的肝病理方面表现有前途.
结论:
- 通过多干预控制ROS产量是肝脏疾病的可行的治疗方法.
- 对聚醇的机制和临床应用进行进一步的研究是有必要的,以控制LIRI,NAFLD和HCC.
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