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乳酪在糖尿病状态下改善体内内皮质线粒体功能和代谢逆氧化状态

Elisa Martino¹, Amalia Luce¹, Anna Balestrieri²

¹Department of Precision Medicine, University of Campania Luigi Vanvitelli, Via L. De Crecchio 7, 80138 Naples, Italy.

Antioxidants (Basel, Switzerland)

|June 28, 2023

概括

乳清蛋白在2型糖尿病 (T2DM) 中通过保护氧化应激和线粒体损伤,改善内皮细胞功能. 这种乳制品副产品显示出作为一种饮食干预措施来管理T2DM并发症的潜力.

科学领域:

生物化学生物化学
细胞生物学细胞生物学
营养科学营养科学

背景情况:

内皮功能障碍是2型糖尿病 (T2DM) 进展和心血管并发症的关键因素.
饮食中的抗氧化剂和线粒体功能支持对T2DM管理至关重要.
乳清 (WH) 是一种乳制品副产品,含有影响细胞代谢的生物活性化合物.

研究的目的:

在T2DM条件下研究乳清对内皮细胞中线粒体功能的影响.
探索乳清作为减轻T2DM相关内皮功能障碍的饮食干预的潜力.

主要方法:

使用暴露于棕酸 (PA) 和高葡萄糖 (HG) 的人类内皮细胞 (TeloHAEC) 进行体外研究,以模仿糖尿病状况.
评估细胞活力,细胞循环,细胞亡,氧化还原平衡,代谢变化和线粒体功能.
分析SIRT3蛋白水平和通过siRNA抑制SIRT3的影响.

主要成果:

乳清显著保护内皮细胞免受PA+HG诱导的细胞毒性,细胞亡和细胞循环停止.
乳清防止了糖尿病内皮细胞的氧化还原失衡和代谢变化.
乳清抵消了线粒体损伤并恢复了SIRT3水平;SIRT3抑制取消了这些保护作用.

结论:

乳清在糖尿病内皮细胞中显示出作为氧化还原和代谢调节剂的有效性.
乳清的保护作用部分是由SIRT3.3介导的.
乳清作为生物活性分子的饮食来源,有望成为预防T2DM并发症的预防策略.

关键词:

在SIRT3中,SIRT3是最重要的.糖尿病糖尿病患者糖尿病患者内皮质功能障碍内皮质功能障碍代谢代谢代谢代谢线粒体中的线粒体.肥胖肥胖肥胖肥胖肥胖肥胖肥胖肥胖乳酪糖是什么意思乳酪糖是什么意思

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