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Updated: Jul 25, 2025

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Nrf2作为治疗点在黑色素瘤中对向疗法的耐药性

Marie Angèle Cucci1, Margherita Grattarola1, Chiara Monge2

  • 1Department of Clinical and Biological Science, University of Turin, Corso Raffaello 30, 10125 Turin, Italy.

Antioxidants (Basel, Switzerland)
|June 28, 2023
PubMed
概括

在黑色素瘤中,有针对性的治疗耐药性是一个主要的挑战. 这项研究表明,由DUB3控制的抗氧化剂调节剂Nrf2通过调节YAP来驱动抗性,并且抑制Nrf2可以恢复治疗灵敏度.

关键词:
A375 细胞系的细胞系在BRAFi/MEKi中使用.D4M细胞系的D4M细胞系的细胞系.在 DUB3 和 DUB3 中,Nrf2 没有任何问题.哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈达布拉芬尼布的使用情况黑色素瘤是一种黑色素瘤.针对性治疗的耐药性是针对性的.特拉美丁尼布 (trametinib) 是一种药物.

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