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蛋白质和全球DNA甲基化调节在脂质代谢障碍中的蛋白质和全球DNA甲基化调节与海洋衍生生物产品

Olaia Martínez-Iglesias¹, Vinogran Naidoo¹, Lola Corzo¹

¹EuroEspes Biomedical Research Center, International Center of Neuroscience and Genomic Medicine, 15165 Bergondo, Corunna, Spain.

|June 28, 2023

概括

鱼类生物产品RCI-1502有效降低脂质,并修改小鼠和脂质不良患者的表观遗传标记. 这表明RCI-1502可以通过向DNA甲基化来治疗心血管疾病.

科学领域:

生物化学生化学
遗传学是一个遗传学.
心血管医学心血管医学

背景情况:

脱脂症是心血管疾病 (CVD) 和中风的主要危险因素.
以前的研究表明,来自欧洲S. pilchardus肌肉的生物产品RCI-1502在食高脂肪饮食 (HFD) 的小鼠中具有降脂作用.

研究的目的:

研究RCI-1502在调节基因表达和DNA甲基化中的治疗潜力.
为了评估RCI-1502对失脂症患者和HFD养的小鼠的影响.

主要方法:

液体染色学-双重质谱学 (LC-MS/MS) 在RCI-1502.2.中确定了蛋白质.
基因表达分析和DNA甲基化试验在HFD养的小鼠和失脂症患者身上进行.
在患者身上分析了血清脂质概况.

主要成果:

RCI-1502含有75种参与心血管疾病相关途径的蛋白质.
在HFD小鼠中,治疗减少了心血管疾病基因的表达 (例如,血管细胞粘附分子,血管素) 并使高DNA甲基化正常化.
脱脂症患者的DNA甲基化水平较高;RCI-1502治疗调节了胆固醇和甘油三水平.

结论:

RCI-1502表现出降脂和表观遗传调节的能力.
研究结果表明,RCI-1502是一种潜在的表观遗传调节器,用于治疗患有失脂血症的人的心血管疾病.

关键词:

通过DNA甲基化.心血管疾病心血管疾病脱脂血症是什么情况表观遗传调节器是一种表观遗传调节器.作为一种药物,它是一种epinutraceutical.

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