化:一种瘤的斗,可以在微环境中欺骗免疫系统
Xiaoman Zhou1, Kaijun Chi1, Chairui Zhang1
1The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China.
Biology
|June 28, 2023
概括
化,瘤细胞上的糖涂层,有助于癌症逃避免疫攻击. 新的研究探讨了针对这种"斗"的治疗方法,以提高癌症治疗的有效性.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 葡萄糖生物学 葡萄糖生物学
背景情况:
- 瘤微环境 (TME) 抑制免疫反应,阻碍癌症治疗.
- 化,一种翻译后的修改,在瘤中积累,使它们无法受到免疫监测.
- 瘤细胞化因其在癌症进展和转移中的作用得到越来越多的认可.
研究的目的:
- 审查了解化在瘤生物学中的作用的最新进展.
- 总结新兴的治疗策略,针对癌症中的化.
主要方法:
- 关于癌症中化现有研究的文献综述.
- 分析与化和免疫相关的单细胞和空间测序数据.
- 化向疗法的临床前和临床发展概述.
主要成果:
- 化显著影响瘤扩散,转移和免疫逃避.
- 正在开发新的治疗方法来抑制化或其下游效应.
- 向酸-Siglec相互作用显示出克服免疫抑制的希望.
结论:
- 化是瘤免疫逃避和进展的关键因素.
- 向化为新型癌症疗法提供了一个有希望的途径.
- 对化机制和有针对性的干预措施的进一步研究是有必要的.
更多相关视频
07:44Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
Published on: November 28, 2019
7.6K
06:54Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion
Published on: June 15, 2019
6.0K
相关概念视频
02:17The Tumor Microenvironment
6.7K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.7K
01:27Tumor Immunotherapy
575
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
575
02:30Metastasis
5.6K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.6K