Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

5.8K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.8K
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

7.4K
The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
7.4K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Platelet concentrates integrated with tissue engineering scaffolds: a promising approach for wound healing application.

Journal of nanobiotechnology·2026
Same author

The rising global burden of gout attributable to kidney dysfunction: a 30-year trend analysis and projections to 2036.

Clinical rheumatology·2026
Same author

Retraction notice to "Polydatin protects against calcium oxalate crystal-induced renal injury through the cytoplasmic/mitochondrial reactive oxygen species-NLRP3 inflammasome pathway" [Biomedicine & Pharmacotherapy 167 (2023) 115621].

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same author

P62 in colorectal cancer: from inflammation suppression to cancer promotion.

Frontiers in immunology·2026
Same author

Versatile Eutectogel Sensor With Tunable Mechanical Properties for Monitoring of Human Bioelectromechanical Signals.

Small methods·2026
Same author

Cu-O-In Bridge Engineering in Cu<sub>2</sub>O/In<sub>2</sub>O<sub>3</sub> Nanowires for Efficient CO<sub>2</sub>-to-CO Electroreduction.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same journal

Research on a Regional Availability Evaluation Model for Road-Area High-Entropy Energy Based on Synergy Factors.

Entropy (Basel, Switzerland)·2026
Same journal

Atmospheric Turbulence Channel Modeling and Performance Analysis of a CO-ZP-OFDM Coherent Optical Communication System for UAV Air-to-Ground Scenarios.

Entropy (Basel, Switzerland)·2026
Same journal

Information Geometry and Asymptotic Theory for SMML Estimators.

Entropy (Basel, Switzerland)·2026
Same journal

Correlation Entropy and Power-Law Kinetics.

Entropy (Basel, Switzerland)·2026
Same journal

Research on the Contagion of Systemic Financial Risk Under the Impact of Climate Risks-From the Perspective of Complex Networks and Machine Learning.

Entropy (Basel, Switzerland)·2026
Same journal

The Statistical-Mechanical Meaning of the Wave Function of Quantum Mechanics.

Entropy (Basel, Switzerland)·2026
查看所有相关文章

相关实验视频

Updated: Jul 25, 2025

Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres
06:52

Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres

Published on: July 22, 2020

6.6K

识别癌症驱动路径基于嘴部养鱼算法

Wei Zhang1,2, Xiaowen Xiang1, Bihai Zhao1,2

  • 1College of Computer Science and Engineering, Changsha University, Changsha 410022, China.

Entropy (Basel, Switzerland)
|June 28, 2023
PubMed
概括
此摘要是机器生成的。

这项研究引入了一种新的口鱼 (MBF) 算法,用于在通路水平上识别癌症驱动基因. 通过考虑突变异质性,MBF算法提高了准确性,超过了现有的方法.

关键词:
生物效应 生物效应 生物效应癌症的进展 癌症的进展司机基因覆盖范围 司机基因覆盖范围司机路径的路径

更多相关视频

Mosaic Zebrafish Transgenesis for Functional Genomic Analysis of Candidate Cooperative Genes in Tumor Pathogenesis
09:45

Mosaic Zebrafish Transgenesis for Functional Genomic Analysis of Candidate Cooperative Genes in Tumor Pathogenesis

Published on: March 31, 2015

11.2K
Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

7.3K

相关实验视频

Last Updated: Jul 25, 2025

Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres
06:52

Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres

Published on: July 22, 2020

6.6K
Mosaic Zebrafish Transgenesis for Functional Genomic Analysis of Candidate Cooperative Genes in Tumor Pathogenesis
09:45

Mosaic Zebrafish Transgenesis for Functional Genomic Analysis of Candidate Cooperative Genes in Tumor Pathogenesis

Published on: March 31, 2015

11.2K
Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

7.3K

科学领域:

  • 基因组学就是基因组学.
  • 生物信息学是一种生物信息学.
  • 计算生物学 计算生物学

背景情况:

  • 识别癌症驱动基因对于理解癌症和开发个性化治疗至关重要.
  • 现有的方法在识别驱动路径时经常忽视突变异质性.
  • 主要组件分析 (PCA) 可以帮助减少复杂性,并考虑共变量数据.

研究的目的:

  • 开发一种用于识别癌症驱动基因在途径水平的新方法.
  • 通过结合突变异质性来解决现有方法的局限性.
  • 提高已识别的驱动基因的准确性和生物相关性.

主要方法:

  • 利用了口鱼 (MBF) 算法,这是一个智能优化技术.
  • 构建了一个最大重量子矩阵模型,将PCA纳入共变量数据.
  • 为覆盖和独家性分配差异权重,以减轻突变异质.
  • 在肺腺癌和质母细胞瘤多形数据集上测试了该方法.

主要成果:

  • 在两个数据集中,MBF方法在10大小的驾驶员路径中实现了80%的识别准确度.
  • 与MDPFinder,Dendrix和Mutex方法相比,MBF表现出更高的性能.
  • 路径丰富分析证实了MBF识别的驱动基因的生物学意义.

结论:

  • 该MBF算法有效地识别癌症驱动基因在途径水平,克服了以前方法的局限性.
  • 该方法能够考虑突变异质性的能力提高了准确性.
  • 已识别的驱动基因在癌症信号通路中起着重要作用,验证了MBF方法.