Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes02:16

Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes

12.6K
The present-day mitochondrial and chloroplast genomes have retained some of the characteristics of their ancestral prokaryotes and also have acquired new attributes during their evolution within eukaryotic cells. Like prokaryotic genomes, mitochondrial and chloroplast genomes neither bind with histone-like proteins nor show complex packaging into chromosome-like structures, as observed in eukaryotes. Unlike mitotic cell divisions observed in eukaryotic cells, mitochondria and chloroplasts...
12.6K
Export of Mitochondrial and Chloroplast Genes02:19

Export of Mitochondrial and Chloroplast Genes

3.7K
A eukaryotic cell can have up to three different types of genetic systems: nuclear, mitochondrial, and chloroplast. During evolution, organelles have exported many genes to the nucleus; this transfer is still ongoing in some plant species. Approximately 18% of the Arabidopsis thaliana nuclear genome is thought to be derived from the chloroplast’s cyanobacterial ancestor, and around 75% of the yeast genome derived from the mitochondria’s bacterial ancestor. This export has occurred...
3.7K
Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

7.7K
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
7.7K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

A large-scale multi-ancestry mitochondrial variant association analysis for cardiometabolic traits.

Nature communications·2026
Same author

Simulation study of the effect of fasteners on the attenuation of orbital ultrasonic guided waves.

PloS one·2026
Same author

A Full-Chain Dataset for Intelligent New Energy Vehicles based on High-fidelity Digital Twin Platform.

Scientific data·2026
Same author

Turep: Detecting cross-cancer tumor-reactive T cells in single-cell and spatial transcriptomics data.

bioRxiv : the preprint server for biology·2026
Same author

Serial Thermal Ablation Induces Abscopal Antitumor Immunity and Reveals Targetable CSF1R-Dependent Resistance in Pancreatic Cancer.

bioRxiv : the preprint server for biology·2026
Same author

Natural Language Processing for Substance Use Disorder Information Extraction: A Systematic Literature Review.

Current addiction reports·2026

相关实验视频

Updated: Jul 25, 2025

Author Spotlight: An Optimized Automated Method for Investigating Retinoic Acid Receptors in Neuronal Mitochondria
08:33

Author Spotlight: An Optimized Automated Method for Investigating Retinoic Acid Receptors in Neuronal Mitochondria

Published on: July 28, 2023

646

线索:用于分析单细胞RNA测序数据中的线粒体变异的计算框架.

Mingqiang Wang1,2, Wankun Deng1, David C Samuels3,4

  • 1Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.

Genes
|June 28, 2023
PubMed
概括

MitoTrace是一个新的R包,用于分析单细胞RNA测序数据中的线粒体遗传变异. 它能够强大地恢复线粒体变异,解决目前异质体分析工具的局限性.

关键词:
在R包中,R包是R包.不同质体性质的异质体.谱系追踪 谱系追踪 谱系追踪线粒体遗传变异的基因变异一个单细胞RNA测序.

更多相关视频

Author Spotlight: High-Throughput Image-Based Quantification of Mitochondrial DNA Synthesis and Distribution
10:47

Author Spotlight: High-Throughput Image-Based Quantification of Mitochondrial DNA Synthesis and Distribution

Published on: May 5, 2023

3.4K
Simultaneous Mapping and Quantitation of Ribonucleotides in Human Mitochondrial DNA
12:35

Simultaneous Mapping and Quantitation of Ribonucleotides in Human Mitochondrial DNA

Published on: November 14, 2017

9.5K

相关实验视频

Last Updated: Jul 25, 2025

Author Spotlight: An Optimized Automated Method for Investigating Retinoic Acid Receptors in Neuronal Mitochondria
08:33

Author Spotlight: An Optimized Automated Method for Investigating Retinoic Acid Receptors in Neuronal Mitochondria

Published on: July 28, 2023

646
Author Spotlight: High-Throughput Image-Based Quantification of Mitochondrial DNA Synthesis and Distribution
10:47

Author Spotlight: High-Throughput Image-Based Quantification of Mitochondrial DNA Synthesis and Distribution

Published on: May 5, 2023

3.4K
Simultaneous Mapping and Quantitation of Ribonucleotides in Human Mitochondrial DNA
12:35

Simultaneous Mapping and Quantitation of Ribonucleotides in Human Mitochondrial DNA

Published on: November 14, 2017

9.5K

科学领域:

  • 基因组学就是基因组学.
  • 分子生物学分子生物学
  • 生物信息学是一种生物信息学.

背景情况:

  • 线粒体基因组中的遗传变异对于生物功能和疾病至关重要.
  • 单细胞RNA测序 (scRNAseq) 是细胞转录学的一个强大工具.
  • 从scRNAseq可以推断出线粒体变异,但缺乏专门的分析工具.

研究的目的:

  • 介绍MitoTrace,一个R包用于分析线粒体遗传变异在散装和scRNAseq数据.
  • 为了解决目前用于线粒体异质质体的变异调用工具的局限性.
  • 为了能够对线粒体变异的单细胞格局进行强有力的调查.

主要方法:

  • 开发了MitoTrace,这是用于线粒体变异分析的R包.
  • 将MitoTrace应用于各种公开可用的scRNAseq数据集.
  • 在不同的scRNAseq平台上验证MitoTrace的性能.

主要成果:

  • MitoTrace成功地从scRNAseq数据中恢复了基因变异.
  • 该软件包证明了它在各种scRNAseq数据类型和平台上的适用性.
  • MitoTrace提供了一种用户友好的方法来对线粒体变体进行调查.

结论:

  • MitoTrace是分析scRNAseq数据中的线粒体遗传变异的有效工具.
  • 该包克服了与称为线粒体异质质体有关的挑战.
  • MitoTrace促进了对单细胞水平上线粒体生物学和疾病的更深入的洞察.