针对COVID-19的非药物干预导致LHON发病年龄下降趋势
Yuxi Zheng1, Xiaoyun Jia1, Shiqiang Li1
1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, 54 Xianlie Road, Guangzhou 510060, China.
COVID-19大流行降低了勒伯遗传性视神经病变 (LHON) 发病的年龄,二手烟和戴口罩成为新的风险因素. LHON患者,尤其是儿童,应该避免这些触发因素.
科学领域:
- 眼科医生 眼科 眼科
- 遗传学 是一个遗传学.
- 流行病学 流行病学
背景情况:
- 勒伯遗传性视神经病变 (LHON) 是一种受环境因素影响的遗传疾病.
- COVID-19大流行及其相关干预措施对LHON发病的影响尚不清楚.
研究的目的:
- 为了调查COVID-19大流行期间LHON发病的变化.
- 确定与非药物干预 (NPHI) 相关的新风险因素.
主要方法:
- 对147名具有m.11778G>A突变的LHON患者的回顾性分析 (2017年1月至2022年7月).
- 在COVID-19前组和COVID-19组之间的发病年龄和风险因素的比较.
- 多变量逻辑回归用于识别独立的风险因素.
主要成果:
- 在COVID-19大流行期间,LHON发病的中位数年龄显著下降 (14.17岁) 与大流行前 (16.65岁) 相比.
- 增加二手烟暴露和戴口罩被确定为早期LHON发病的独立风险因素.
- 在NPHI期间的生活方式的改变包括增加的烟雾暴露,口罩坚持,减少户外休和长时间的屏幕时间.
结论:
- COVID-19大流行与LHON早期发病有关,特别是在年轻人中.
- 暴露于二手烟和长时间佩戴口罩被确定为早期LHON发病的重要风险因素.
- 建议建议LHON突变携带者,特别是儿童,避免二手烟,并考虑长时间使用口罩的潜在风险.
更多相关视频
09:03Nasal Brushing Sampling and Processing Using Digital High Speed Ciliary Videomicroscopy – Adaptation for the COVID-19 Pandemic
Published on: November 7, 2020
07:38Isolation of Tonsillar Mononuclear Cells to Study Ex Vivo Innate Immune Responses in a Human Mucosal Lymphoid Tissue
Published on: June 14, 2020
相关概念视频
Longitudinal Research
Prevalence and Incidence
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
Factors Affecting Illness
For instance, risk factors are connected to illness,...
COPD: Pathogenesis and Clinical Features
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
Lifestyle Factors and Health
Benefits of Physical Activity
Physical activity, whether through structured exercise or casual activities like walking, biking, or dancing, is a cornerstone of a...
Bias in Epidemiological Studies
