淋巴激素及其受体的遗传变异可能影响受控卵巢刺激:来自前性多中心研究的试管婴儿数据
Carlo Alviggi1, Salvatore Longobardi2, Enrico Papaleo3
1Department of Public Health, University of Naples Federico II, Via Sergio Pansini, 80131 Naples, Italy.
Genes
|June 28, 2023
概括
特定的基因变异会影响接受辅助生殖技术 (ART) 的女性的卵巢刺激反应. 基因型定制可能为未来的见解提供帮助,但在ART的临床应用中需要进一步的研究.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 人类遗传学 人类遗传学
- 辅助生殖技术 辅助生殖技术
背景情况:
- 遗传变异,特别是多态性,可能会影响接受辅助生殖技术 (ART) 的妇女的受控卵巢刺激结果.
- 关于这些多态的交互效应的数据有限.
- 了解这些遗传因素对于优化ART协议至关重要.
研究的目的:
- 评估性腺激素及其受体中的多态性对接受ART的女性受控卵巢刺激的影响.
- 研究这些遗传标记物之间的潜在相互作用及其对治疗反应的影响.
主要方法:
- 研究了一组由接受ART的94名正常性腺素患者组成的队列.
- 患者接受了长时间下调的淋巴激素释放激素 (GnRH) 和复合毛囊刺激激素 (FSH) 的治疗方案.
- 八种特定的多态形态被基因型化.
主要成果:
- 与异构卵性携带者相比,黄素化激素/胆激素受体 (LHCGR) 291 (T/T) 的同卵性携带者获得的卵细胞较少.
- 卵泡刺激激素受体 (FSHR) 多态性 (rs6165,rs6166) 影响了淋巴激素消耗与获得卵子细胞的比率.
- 在FSHR和LHCGR的组合多态性与FSH总剂量与收集的卵细胞的比例显著增加有关.
结论:
- 特定的遗传多形态明显影响对受控卵巢刺激的反应.
- 虽然这些发现表明潜在的临床实用性,但需要进一步的强有力的研究.
- 基因型分析最终可能有助于个性化ART的卵巢刺激协议.
相关概念视频
Hormonal Control of the Ovarian Cycle
592
The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
592
Gonadal and Placental Hormones
1.6K
The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
1.6K
Oogenesis
63.9K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.9K
Infertility in Females
353
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
Endometriosis, a condition characterized by abnormal growth of...
353
In Vitro Fertilization
336
In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
336
Genetic Variation
331
Genetic variation is the diversity in DNA sequences found among individuals of the same species. This diversity is crucial for a species' survival because it helps organisms adapt to environmental changes. Genetic variation begins with fertilization, where an egg and sperm cell merge. Each of these cells carries 23 chromosomes, up to 46 in the fertilized egg. Chromosomes are long DNA strands that contain genes, the basic units of heredity.
Genes exist in different versions called alleles,...
Genes exist in different versions called alleles,...
331


