对RICTOR的潜在生物功能和预后值进行全面的全癌症分析
Ying Sun1,2, Rui Li2, Baoting Nong3
1Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Genes
|June 28, 2023
概括
在许多癌症中,mTOR (RICTOR) 的不敏感拉巴胺素伴侣对瘤细胞存活和进展至关重要. 高RICTOR表达与低生存率相关,突出其作为预后标记物的潜力.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 酸丁醇-3-酶 (PI3K) /AKT/哺乳动物目标的拉巴胺素 (mTOR) 途径在癌症中至关重要.
- 在这种途径中,RICTOR (mTOR的拉皮素不敏感伴侣) 的作用越来越被认可,但需要进一步的泛癌研究.
研究的目的:
- 系统地阐明RICTOR在各种癌症类型中的分子特性和临床预后价值.
- 研究RICTOR在瘤细胞中的依赖性及其与遗传变异和免疫微环境的关系.
主要方法:
- 对RICTOR表达的泛癌分析及其与整体存活率的相关性.
- 为了评估RICTOR对瘤细胞存活的必要性,CRISPR的阿基里斯结核查.
- 对RICTOR与遗传改变,DNA甲基化和免疫细胞透的关联进行分析.
- 在 HeLa 细胞中使用细胞循环,增殖和伤口愈合试验进行体外验证.
主要成果:
- 在12种癌症类型中,RICTOR过度表达,高表达与较低的整体存活率有关.
- RICTOR被确定为瘤细胞存活的关键基因.
- 瑞克托表达受遗传变化和DNA甲基化的影响.
- 在特定癌症中,RICTOR表达与巨细胞和癌症相关的纤维细胞透正相关.
- 瑞克托在体外促进瘤生长和入侵.
结论:
- 在胰腺癌的进展中,RICTOR起着至关重要的作用.
- RICTOR是各种癌症类型的潜在预后生物标志物.
- 准RICTOR可能为癌症治疗提供治疗机会.
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