乳酸的微生物发酵过程:挑战,解决方案和未来前景
Yueying Huang1, Yu Wang1, Nan Shang2
1Key Laboratory of Functional Dairy, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.
Foods (Basel, Switzerland)
|June 28, 2023
概括
微生物发酵提供了高效的乳酸生产,但面临着原料成本和产品抑制等挑战. 本综述总结了工业乳酸发酵的解决方案.
科学领域:
- 生物技术是生物技术.
- 工业微生物学 工业微生物学
背景情况:
- 乳酸需求在食品,制药和化品行业不断增加.
- 微生物发酵是乳酸的首选方法,因为它具有较高的光学纯度,成本效益和效率高于化学合成.
- 微生物发酵的关键步骤包括原料,菌株和模式的选择,影响产量和纯度.
研究的目的:
- 审查乳酸生产微生物发酵的局限性和挑战.
- 总结克服这些障碍的潜在解决方案.
- 为工业规模的乳酸发酵提供指导.
主要方法:
- 关于生产乳酸的微生物发酵过程的文献综述.
- 分析挑战,包括原料/能源成本,基质/产品抑制,以及对抑制化合物的敏感性.
- 识别和总结拟议的解决方案和战略.
主要成果:
- 乳酸发酵仍然存在重大挑战,包括经济因素和生物限制.
- 原料成本,能源消耗,基质和最终产品的抑制以及对预处理抑制剂的敏感性是主要障碍.
- 在某些发酵过程中,较低的光学纯度仍然是一个问题.
结论:
- 应对已确定的挑战对于优化工业乳酸生产至关重要.
- 实施有效的策略可以提高产量,纯度和成本效益.
- 本综述提供了洞察力,以指导未来的乳酸发酵研究和工业应用.
相关概念视频
Microbial Fermentation
88
Fermentation is a crucial anaerobic metabolic process that enables microbes to derive energy from sugar without relying on oxygen or an electron transport chain. This process is fundamental to various biological and industrial applications and is classified based on the metabolic products generated.Role of Pyruvate in FermentationPyruvate and its derivatives serve as key electron acceptors in fermentative pathways. The oxidation of NADH to regenerate NAD+ is essential for the continuation of...
88
Fates of Pyruvate
8.7K
Pyruvate is the end product of glycolysis, where glucose is oxidized to pyruvate, simultaneously reducing NAD+ to NADH. Two molecules of ATP are also produced by substrate-level phosphorylation.
In aerobic organisms, pyruvate is metabolized via the citric acid cycle to produce reduced coenzymes NADH and FADH2. These coenzymes are then oxidized in the electron transport chain to produce ATP and, in the process, regenerate the NAD+ and FAD. As seen in some cell types and organisms, fermentation...
In aerobic organisms, pyruvate is metabolized via the citric acid cycle to produce reduced coenzymes NADH and FADH2. These coenzymes are then oxidized in the electron transport chain to produce ATP and, in the process, regenerate the NAD+ and FAD. As seen in some cell types and organisms, fermentation...
8.7K
Microorganisms in Agriculture and Food industry
96
Microorganisms play a crucial role in agriculture and the food industry, contributing to soil fertility, crop protection, and food production. Their functions range from nitrogen fixation and biopesticide production to fermentation and food preservation, making them indispensable to sustainable farming and food safety.Role in AgricultureNitrogen-fixing bacteria, such as Rhizobium (symbiotic) and Azotobacter (free-living), convert atmospheric nitrogen into ammonia through biological nitrogen...
96
Environmental Applications of Microorganisms
75
Microorganisms play a pivotal role in maintaining ecosystem balance by recycling essential elements such as carbon, nitrogen, and phosphorus, as well as supporting processes like bioremediation, wastewater treatment, and biofuel production.Microbes in Elemental CyclesIn the carbon cycle, microorganisms decompose organic matter, releasing carbon dioxide via aerobic respiration. This carbon dioxide is subsequently used by photosynthetic organisms to synthesize organic compounds, closing the...
75
Factors Influencing Microbial Growth: Temperature
69
Microorganisms display remarkable adaptations, enabling them to thrive in diverse ecological niches across a wide range of temperatures. Temperature profoundly influences microbial growth by affecting enzymatic activity, membrane fluidity, and other cellular processes.Each microorganism operates within a specific temperature range defined by three cardinal points: minimum, optimum, and maximum. Below the minimum temperature, membranes lose fluidity, halting transport processes. Above the...
69
Overview of Archaea
51
Archaea, named after the Archaean eon, represent a unique domain of life, distinct from bacteria and eukaryotes, with remarkable traits. Their cellular and molecular features, ecological adaptability, and industrial relevance highlight their importance in understanding life processes and leveraging biotechnology.Cellular and Molecular CharacteristicsA defining feature of archaea is their unique membrane composition. Archaeal membranes contain ether-linked isoprenoid lipids, which confer...
51


