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通过纳米悬浮和纳米乳液技术开发植物化学输送系统

Guendalina Zuccari¹, Silvana Alfei¹

¹Department of Pharmacy (DiFAR), University of Genoa, Viale Cembrano 4, I-16148 Genova, Italy.

International journal of molecular sciences

|June 28, 2023

概括

植物植物化学物质 (PHY) 提供健康益处,但面临生物可用性挑战. 纳米技术,使用纳米悬浮和纳米乳液,增强了潜在的治疗应用的PHY交付,尽管纳米毒性需要进一步研究.

科学领域:

药理学和纳米技术的应用
自然产品化学自然产品化学
药物输送系统药物输送系统

背景情况:

植物衍生植物化学物质 (PHY) 具有多种促进健康的特性,包括抗氧化,抗炎和抗菌作用.
尽管PHY具有潜力,但其水溶性较差,生物可用性较低,并迅速降解,限制了其治疗效果.
纳米技术提供了创新的解决方案,以克服这些局限性,并提高PHYs的交付.

研究的目的:

审查基于纳米悬浮和纳米乳液的技术,用于将植物化学物质制成纳米粒子 (NP).
评估这些纳米配方PHYs的适合性和前景,用于临床应用,特别是口服.
讨论NP暴露的毒理学方面以及PHY和纳米PHY的当前临床状态.

主要方法:

关于关键植物化学品的纳米悬浮和纳米乳液配方的案例研究的文献综述.
对纳米封装PHYs改善生物可用性和治疗潜力的数据分析.
检查报告的与纳米粒子暴露相关的急性和慢性毒性数据.

主要成果:

纳米悬浮和纳米乳液技术有效地提高了各种植物化学品的生物可用性.
开发的纳米颗粒显示出口服和临床应用的前景.
对NP毒性的现有数据进行了审查,突出了需要进一步研究的领域.

结论:

纳米技术提供了有效的策略,以改善植物植物化学物质的传递和治疗潜力.
纳米配方PHY对临床使用具有前景,特别是通过口服.
对纳米毒性和临床应用的持续研究对于纳米PHYs的进步至关重要.

关键词:

急性和慢性纳米毒性植物的生物活性成分植物的生物活性成分临床应用临床应用药物输送系统 (DDS) 是一种药物输送系统.纳米乳液技术的使用方法纳米悬浮技术的使用方法纳米技术应用应用植物化学品 (PHYs) 的使用水溶性较差的水溶性关于NP的毒理风险关于NP的毒理风险

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