遗传对牛皮治疗反应的影响:对个性化医学的新见解
Emilio Berna-Rico1, Javier Perez-Bootello1, Carlota Abbad-Jaime de Aragon1
1Department of Dermatology, Hospital Universitario Ramón y Cajal, IRYCIS, Colmenar Viejo km 9.100, 28034 Madrid, Spain.
International journal of molecular sciences
|June 28, 2023
概括
遗传变异会影响牛皮治疗的有效性. 像VDR这样的基因中的多态性以及影响ABC转运器和抗TNF-α反应的基因具有潜力,可以作为个性化牛皮护理的生物标志物.
科学领域:
- 皮肤病学 皮肤病学
- 遗传学 遗传学 是一个
- 药理学 药理学是指药理学的学科.
背景情况:
- 牛皮是一种具有已知的遗传基础的慢性炎症性皮肤病.
- 现有的牛皮治疗方法对许多患者有效,但并非所有患者.
- 遗传变异可能会影响个体对治疗的反应.
研究的目的:
- 审查关于遗传变异如何影响牛皮治疗结果的证据.
- 为了确定潜在的遗传生物标志物来预测治疗反应.
- 探索银病管理中的药物遗传学和药物遗传学关联.
主要方法:
- 对114篇文章进行了全面的文献综述.
- 现有研究成果的定性综合.
- 专注于遗传多态性及其与治疗疗效和毒性的关系.
主要成果:
- 维生素D受体 (VDR) 基因多态可能会影响对维生素D类似物和光疗的反应.
- 亚贝克转运体变异与甲状腺和环素的结果有关.
- 对于TNF-α,IL-17和IL-23等基因的单核酸多态性,在抗TNF-α治疗反应中存在不同的结果.
- HLA-Cw*06等位基因与乌斯特基努马布反应密切相关.
结论:
- 遗传变异在调节对各种牛皮治疗的反应方面发挥着作用.
- 某些基因多态性显示出作为预测生物标记物的前景.
- 需要进一步的研究来验证这些遗传标记在个性化牛皮治疗中临床应用.
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