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Updated: Jul 25, 2025

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
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合成和抗癌活动的A环修饰的衍生物Dihydrobetulin

Irina Tolmacheva1, Yulia Beloglazova1, Mikhail Nazarov1

  • 1Perm Federal Scientific Centre, Institute of Technical Chemistry UB RAS, Academician Korolev St. 3, 614013 Perm, Russia.

International journal of molecular sciences
|June 28, 2023
PubMed
概括

一种新的甲基衍生物 (MK) 显示出强大的抗癌活性对抗多药耐药细胞. 尽管最初的预测,MK不抑制P-葡萄糖蛋白,但诱导癌细胞通过线粒体通路死亡.

关键词:
这是一种P-glycoprotein蛋白.这就是ROSOS ROS.灭症 (apoptosis) 是一种死亡的过程.细胞毒性 细胞毒性双贝图林 (dihydrobetulin) 是一种二贝图林 (dihydrobetulin) 的一种.药物耐药性 耐药性 药物耐药性内在路径的内在路径.这是三烯酸类的三烯酸.

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