新的3 - 氨基西拉衍生物:合成,结构,特性和生物活性
Sergey N Adamovich1, Igor A Ushakov1, Elizaveta N Oborina1
1A.E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, 1 Favorsky Street, 664033 Irkutsk, Russia.
International journal of molecular sciences
|June 28, 2023
概括
通过阿扎-迈克尔反应合成的混合西拉坦具有潜力作为具有抗瘤和巨刺激活性的生物可用药物. 它们还对致病性细菌的生长表现出度依赖的影响.
科学领域:
- 有机化学 有机化学
- 药用化学 医学化学
- 计算化学的计算化学
背景情况:
- 西拉是一种有机化合物,具有五坐标原子.
- 阿扎-迈克尔反应对于合成功能化有机分子具有多样性.
- 混合的轮结合了轮的支架与其他功能组.
研究的目的:
- 通过阿扎-迈克尔反应合成新型功能化西拉.
- 描述合成的化合物并评估它们的物理化学性质.
- 预测和评估新型西拉的生物活动.
主要方法:
- 3-aminopropylsilatrane与各种迈克尔受体之间的阿扎-迈克尔反应.
- 光谱 (IR,NMR) 和光谱 (MS) 鉴定.
- 用X射线衍射和元素分析进行结构确认.
- 在Silico,PASS和SwissADMET软件中用于生物可用性和药物相似性预测.
- 关于致病性细菌生长抑制的体外研究.
主要成果:
- 已经成功合成了11种新型迈克尔单体和西拉特兰管.
- 合成的混合西拉被描述并确认具有生物可用性和药物相似性.
- 化合物表现出显著的抗瘤和巨细胞殖民地刺激活性.
- 实验室研究表明,度对细菌生长的影响依赖于度 (高度的抑制,低度的刺激).
结论:
- 通过阿扎-迈克尔反应合成的功能化西拉是一种有前途的化合物类别.
- 这些混合酸盐具有有利的药理动力学特性和强大的生物活性.
- 这些发现表明,这些西拉衍生物在瘤学和传染病中的潜在治疗应用.
相关概念视频
Adrenergic Agonists: Chemistry and Structure-Activity Relationship
3.1K
Adrenergic agonists' structure-activity relationship (SAR) determines their selectivity and efficacy. These agonists comprise a phenylethylamine moiety with an aromatic ring and an ethylamine side chain.
Aromatic ring substitutions: Substituting the aromatic ring with –OH groups at positions 3 and 4 yields catecholamines (e.g., epinephrine), which have a high affinity for adrenoceptors. Hydrogen bonding between –OH groups and receptors enhances adrenergic activity.
Separation of...
Aromatic ring substitutions: Substituting the aromatic ring with –OH groups at positions 3 and 4 yields catecholamines (e.g., epinephrine), which have a high affinity for adrenoceptors. Hydrogen bonding between –OH groups and receptors enhances adrenergic activity.
Separation of...
3.1K
Preparation of 1° Amines: Gabriel Synthesis
3.6K
Direct alkylation is not a suitable method for synthesizing amines because it produces polyalkylated products. Gabriel synthesis is the most preferred method to exclusively make primary amines. The method uses phthalimide, which contains a protected form of nitrogen that participates in alkylation only once to predominantly give primary amines.
Strong bases like NaOH or KOH deprotonate the phthalimide to form the corresponding anion, which acts as a nucleophile. Further, the anion attacks an...
Strong bases like NaOH or KOH deprotonate the phthalimide to form the corresponding anion, which acts as a nucleophile. Further, the anion attacks an...
3.6K
Diazonium Group Substitution: –OH and –H
2.8K
Nitrous acid, a weak acid, is prepared in situ via the reaction of sodium nitrite with a strong acid under cold conditions. This nitrous acid prepared in situ reacts with primary arylamines to form arenediazonium salts. Such reactions are known as diazotization reactions. As shown in Figure 1, the formation of arenediazonium salts begins with the decomposition of nitrous acid in an acidic solution to give nitrosonium ions.
2.8K
Structure-Activity Relationships and Drug Design
794
Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
794
Preparation and Reactions of Sulfides
4.9K
Sulfides are the sulfur analog of ethers, just as thiols are the sulfur analog of alcohol. Like ethers, sulfides also consist of two hydrocarbon groups bonded to the central sulfur atom. Depending upon the type of groups present, sulfides can be symmetrical or asymmetrical. Symmetrical sulfides can be prepared via an SN2 reaction between 2 equivalents of an alkyl halide and one equivalent of sodium sulfide.
4.9K
Nomenclature of Carboxylic Acid Derivatives: Amides and Nitriles
4.2K
Naming Amides
The IUPAC and common names of amides are derived from the parent carboxylic acid, by replacing the suffix “oic acid” and “ic acid,” respectively, with “amide.” In the following example, the IUPAC name ethanamide is derived from ethanoic acid, and the common name, acetamide, is obtained from acetic acid.
The IUPAC and common names of amides are derived from the parent carboxylic acid, by replacing the suffix “oic acid” and “ic acid,” respectively, with “amide.” In the following example, the IUPAC name ethanamide is derived from ethanoic acid, and the common name, acetamide, is obtained from acetic acid.
4.2K


