可卡因和胺调节转录 (CART) 在癌症中的作用:系统性审查
Maja Owe-Larsson1, Jan Pawłasek1, Tomasz Piecha2
1Department of Histology and Embryology, Center of Biostructure Research, Medical University of Warsaw, Chałubińskiego 5, 02-004 Warsaw, Poland.
International journal of molecular sciences
|June 28, 2023
概括
可卡因和胺调节的转录蛋白 (CART) 参与癌症的发展和进展. 在各种瘤疾病中,CART可以作为生物标志物和治疗点.
科学领域:
- 分子生物学分子生物学
- 在瘤学瘤学.
- 神经科学是一个神经科学.
背景情况:
- 由CARTPT基因编码的可卡因和胺调节转录 (CART) 神经具有多种功能,包括行为修饰,疼痛敏感性和抗氧化活性.
- 卡特受体GPR160与癌症病原发生有关,但卡特蛋白在瘤发展中的确切作用尚未完全理解.
研究的目的:
- 系统地审查和分析关于CART与癌症之间的关联的现有文献.
- 阐明CART蛋白在不同类型癌症的发展和进展中的作用.
主要方法:
- 在Scopus,PubMed,Web of Science和Medline Complete数据库中进行了系统的文献搜索.
- 分析了19篇符合纳入标准的出版物,这些出版物描述了CART与癌症的关联.
主要成果:
- 在多种癌症中表达CART,包括乳腺癌和神经内分泌瘤 (NETs).
- 建议CART作为潜在的生物标志物的作用是乳腺癌,胃腺癌,质瘤和某些NET.
- 在癌症细胞系中,CART作为瘤基因起作用,通过ERK通路激活促进细胞存活,抑制细胞亡,并增加cyclin D1水平. 它还保护乳腺癌细胞免受他莫西芬诱导的死亡.
结论:
- 这些数据强烈支持CART在癌症发病过程中的参与.
- 在瘤疾病中,CART活动为诊断和治疗策略提供了潜在的新途径.
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