布利祖马布和尼沃卢马布的分子养殖
Michael C Stark1, Anna M Joubert1, Michelle H Visagie1
1Department of Physiology, School of Medicine, Faculty of Health Sciences, University of Pretoria, Private Bag X323, Pretoria 0031, South Africa.
International journal of molecular sciences
|June 28, 2023
概括
分子农业提供了一个低成本,可扩展的解决方案,用于生产免疫检查点抑制剂 (ICI),如pembrolizumab和nivolumab. 这种基于植物的生物制造方法可以改善低收入国家的这些重要癌症治疗方法的可用性.
科学领域:
- 免疫学 免疫学 免疫学
- 生物技术是生物技术.
- 在瘤学瘤学.
背景情况:
- 免疫检查点抑制剂 (ICI) 通过抵消瘤细胞的免疫抑制来对抗癌症.
- PD-1/PD-L1通路对于瘤免疫逃避至关重要,抑制T细胞功能.
- 目前的PD-1/PD-L1抑制剂,布罗利祖马布和尼沃卢马布,价格昂贵,在LMIC中无法获得.
研究的目的:
- 探索分子农业作为单克隆抗体 (mAbs) 具有成本效益的生物制造平台.
- 解决低收入和中等收入国家 (LMICs) 基本癌症免疫疗法的可访问性限制.
主要方法:
- 使用植物作为生物反应器生产针对PD-1/PD-L1免疫检查点的mAbs.
- 评估分子农业在快速,可扩展和低成本的mAb生成方面的潜力.
主要成果:
- 分子农业提供了一个可行的策略,用于生产治疗 mAbs.
- 该平台显示了在ICI制造业显著降低成本的潜力.
- 这种方法是快速的,可扩展的,适合在LMICs实施.
结论:
- 分子农业可以降低PD-1/PD-L1抑制剂的成本,提高全球可访问性.
- 实施基于植物的mAb生产可以降低LMICs的癌症死亡率.
- 这种生物制造创新有望为全球平等的癌症治疗提供希望.
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