双极性障碍中的RNA生物标志物和对情绪稳定剂的反应
Claudia Pisanu1, Alessio Squassina1,2
1Department of Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, 09042 Monserrato, Italy.
International journal of molecular sciences
|June 28, 2023
概括
双极性障碍 (BD) 缺乏可靠的生物标志物来诊断或治疗反应. RNA转录,包括信使RNA和非编码RNA,显示出作为BD及其治疗结果的外围标记物的潜力.
科学领域:
- 神经科学是一个神经科学.
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 双极性障碍 (BD) 是导致残疾的重要原因,特别是在年轻人中.
- 目前对BD的诊断和治疗反应评估缺乏可靠的生物标志物.
- RNA转录提供了超越全基因组关联研究的潜在互补见解.
研究的目的:
- 审查关于RNA转录作为双极性障碍 (BD) 外围标记物的有用性的人类研究.
- 评估RNA生物标志物,以预测对等情绪稳定剂的临床反应.
- 探索编码和非编码RNA在BD病原和治疗中的作用.
主要方法:
- 对研究信使RNA,microRNA,圆形RNA和长非编码RNA的人类研究的叙述性综述.
- 对研究的分析,重点关注BD诊断和治疗反应的外围标志物.
- 包括使用有针对性和无假设设计的研究,包括集成的RNA数据.
- 考虑来自诱导多能干细胞衍生的神经元和大脑器官的发现.
主要成果:
- 在研究设计,细胞类型和检查RNA标记物的生物流体中存在异质性.
- 越来越多的研究采用无假设方法,并整合编码和非编码RNA数据.
- 来自iPSC衍生神经元和大脑器官等细胞模型的初步发现显示出有希望.
- 使者RNA和各种非编码RNA正在作为BD.的潜在外围生物标志物进行研究.
结论:
- 包括编码和非编码类型在内的RNA转录代表了在双相情感障碍中识别生物标志物的有前途领域.
- 进一步研究整合多种RNA类型和先进的细胞模型对于开发可靠的诊断和预后工具至关重要.
- 外围RNA标记物可以通过告知诊断和治疗选择,显著改善双相情感障碍的临床管理.
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