中心和外周炎症:导致上和神经障碍以及与衰老相关的疾病的常见因素
Angélica P Escobar1, Christian Bonansco1, Gonzalo Cruz1
1Centro de Neurobiología y Fisiopatología Integrativa (CENFI), Instituto de Fisiología, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso 2360102, Chile.
International journal of molecular sciences
|June 28, 2023
概括
现代生活方式和衰老引发炎症,恶化成,神经精神和心脏代谢疾病. 针对炎症途径可能为这些疾病提供治疗效益.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 炎症级联是由影响神经系统和外围器官的疾病激活的.
- 诸如成,压力,衰老和现代生活方式 (包括COVID-19的限制) 等危险因素会加剧炎症.
- 增加成性,神经精神和心脏代谢疾病的发病率与这些因素有关.
研究的目的:
- 审查将生活方式驱动的炎症与神经病理和不良健康行为联系在一起的证据.
- 阐明各种组织中炎症的细胞和分子机制.
- 探索疾病进展中的行为和炎症之间的循环关系.
主要方法:
- 文献审查和现有证据的综合.
- 讨论炎症的细胞和分子机制.
- 分析行为和炎症途径之间的相互作用.
主要成果:
- 中央和外周炎症是由各种风险因素激活的,导致神经病理.
- 特定的细胞和分子机制在不同的组织中驱动炎症,促进疾病.
- 病理相关和成行为创造了一个恶性循环,使炎症和疾病进展恶化.
结论:
- 生活方式因素显著影响炎症过程,导致一系列慢性疾病.
- 了解这些机制对于开发有针对性的疗法至关重要.
- 针对特定途径的抗炎药物显示出治疗成,精神和心脏代谢疾病的潜力.
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