植物作为内生植物的扩展表型 - - 生物活性化合物的实际来源
Natalia Rutkowska1, Piotr Drożdżyński1, Małgorzata Ryngajłło1
1Institute of Molecular and Industrial Biotechnology, Lodz University of Technology, Stefanowskiego 2/22, 90-537 Lodz, Poland.
International journal of molecular sciences
|June 28, 2023
概括
植物内的内菌微生物可以产生有价值的药用化合物,为传统的植物提取提供可持续的替代品. 了解它们的生物合成途径是释放它们对制药产业潜力的关键.
科学领域:
- 生物技术是生物技术.
- 微生物学 微生物学
- 药理学是指药理学,即药理学是指药理学.
背景情况:
- 传统的植物医学面临着诸如季节性变化和难以提取,物种威胁和供应限制等挑战.
- 对植物化合物的需求不断增长,特别是用于癌症治疗,需要可持续的生产方法.
- 生活在植物组织中的内性微生物显示出在体外产生类似生物活性化合物的潜力.
研究的目的:
- 探索植物内内细胞产生的宿主特异性化合物的生物合成路径.
- 调查由内细胞产生生物活性化合物的基础上的分子机制.
- 为克服大规模实施内植物用于化合物生产的局限性提供见解.
主要方法:
- 文献综述侧重于植物特异性化合物的生物合成途径在内菌中.
- 分析分子机制和内菌化合物生产的遗传背景.
- 来自宿主植物及其相关内植物的化合物概况的比较研究.
主要成果:
- 内植物能够合成与其宿主植物产生的化合物相同或类似的化合物.
- 植物内性生活方式影响生物活性化合物的生物合成,引发了关于主要生产者 (植物与内性) 的问题.
- 了解这些途径对于优化基于内菌的生产系统至关重要.
结论:
- 内植物是药用化合物的有希望的可持续来源,减少了对危植物物种的压力.
- 对于生物技术应用来说,对内生菌生物合成的分子基础的进一步研究是必不可少的.
- 利用内植物可以彻底改变用于制药用途的有价值的天然产品的生产.
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