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生物化学目标和对抗衰老的Matrine的分子机制

Kaiyue Sun¹, Yingzi Zhang¹, Yingliang Li¹

¹College of Veterinary Medicine, Shanxi Agricultural University, Taigu, Jinzhong 030801, China.

International journal of molecular sciences

|June 28, 2023

概括

马林 (MAT) 通过向PARP1/尼古丁胺胺氨基二核酸 (NAD+) 途径来对抗衰老. 这种天然化合物稳定了Poly [ADP-ribose]聚合酶-1 (PARP1) 并提高了NAD+水平,这表明了一种新的抗衰老机制.

科学领域:

老年病学和药理学
计算生物学和生物信息学
分子生物学分子生物学

背景情况:

衰老是一个复杂的过程,受遗传和分子因素的影响.
孕 (MAT) 是一种具有潜在治疗应用的天然化合物.
了解抗衰老干预措施的分子机制至关重要.

研究的目的:

为了确定对抗衰老的母体蛋白 (MAT) 的潜在分子标.
为了阐明MAT抗衰老作用背后的分子机制.
研究PARP1/NAD+途径在MAT介导的抗衰老中的作用.

主要方法:

基于生物信息的网络药理学被用来识别与衰老相关的和MAT治疗的目标.
使用分子复杂检测和中心性算法过了关键基因.
Metascape工具被用于途径和生物过程丰富分析.
分子对接,分子动力学模拟和体内研究验证了这些发现.

主要成果:

确定了与MAT相关的193个潜在的抗衰老基因,突出显示了10个关键基因.
主要的生物过程包括对无机物质和细胞应激的反应,特别是氧化应激.
关键途径涉及细胞衰老和细胞循环,涉及PARP1/NAD+信号传递.
分子对接和动力学证实了MAT和PARP1之间的稳定结合.
在体内研究表明,MAT能够增加老化小鼠的肝脏NAD+水平.

结论:

孕妇 (MAT) 通过调节PARP1/NAD+介导的细胞衰老途径,表现出抗衰老的潜力.
MAT和PARP1之间的相互作用是其抗衰老作用的关键因素.
通过其对细胞衰老和NAD+代谢的影响,MAT代表了对抗衰老的有前途的治疗剂.

关键词:

在PARP1/NAD+中.老化的老化衰老的老化孕妇 (matrine) 是一个母亲.网络药理学网络药理学

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