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长期治疗皮奥格利塔对P301S小鼠的微细胞活化和tau病理没有显著影响

Lea Helena Kunze^1,2, François Ruch¹, Gloria Biechele³

¹Department of Nuclear Medicine, University Hospital of LMU Munich, Marchioninistraße 15, 81377 Munich, Germany.

International journal of molecular sciences

|June 28, 2023

概括

抗糖尿病药物皮奥格利塔在病症的小鼠模型中没有显著影响微质激活或病理. 这表明皮奥格利塔可能不是对相关神经退行症的有效治疗方法.

科学领域:

神经科学是一个神经科学.
免疫学免疫学免疫学
药理学药理学是指药理学的学科.

背景情况:

神经炎症是神经退行性疾病的关键因素,如初级病.
过氧体增殖器激活受体γ (PPARγ) 激动剂,如皮奥格利塔,调节免疫反应.
之前的研究表明,皮奥格利塔在粉样β模型中具有免疫调节作用.

研究的目的:

为了研究皮奥格利塔对神经炎症和病理的长期影响,在病症的小鼠模型中.
用TSPO-PET成像和免疫组织化学评估皮奥格利塔对微质激活的影响.

主要方法:

长期 (六个月) 的pioglitazone或安慰剂在P301S病模式小鼠的管理.
连续18kDa转位蛋白质正子发射断层扫描 (TSPO-PET) 成像,以监测微质激活.
终端免疫组织化学测量微质激活和病理.

主要成果:

长期治疗皮奥格利塔对TSPO-PET信号,微质激活标志物或tau病理水平没有显著影响.
在粉样β模型中观察到的皮奥格利塔的免疫调节效应在这种病模型中没有复制.

结论:

皮奥格利塔在粉样β病理中调节微质激活,但不会显著改变微质对tau病理的反应.
这些发现表明,皮奥格利塔可能不是对原发性陶病症的可行的治疗策略.

关键词:

在TSPO-PET中.微质细胞中的微质细胞皮奥格利塔 (pioglitazone) 是一种药物.

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