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袖子胃切除术后12个月血清中催产素水平下降,并且与瘦肉量减少有关
Imen Becetti1,2, Vibha Singhal1,2,3, Supritha Nimmala2
1Division of Pediatric Endocrinology, Mass General for Children and Harvard Medical School, Boston, MA 02114, USA.
International journal of molecular sciences
|June 28, 2023
概括
在袖子胃切除术后,催产素 (OXT) 水平降低,影响瘦肉质量. 准OXT途径可能有助于防止减肥手术后的瘦质量损失.
科学领域:
- 内分泌学 在内分泌学.
- 代谢手术 代谢手术
- 骨生物学 骨生物学 骨生物学
背景情况:
- 催产素 (OXT) 是一种具有骨类 anabolic 特性的厌食激素.
- 在成年人中,OXT的使用增加了肥胖症的瘦肉量 (LM).
研究的目的:
- 调查OXT,身体组成和严重肥胖的青少年和年轻成年人进行袖子胃切除术 (SG) 的骨健康之间的关联.
- 为了在12个月内比较SG患者和非手术对照者之间的OXT水平和身体组成的变化.
主要方法:
- 对25名患有严重肥胖的年轻人 (13-25岁) 进行前性研究,他们接受了SG和27名非手术对照.
- 禁食血清OXT水平和DXA扫描区域骨矿物质密度 (aBMD) 和身体组成在基线和12个月后被评估.
- 统计分析以确定OXT,BMI,LM,脂肪质量 (FM) 和aBMD之间的关联.
主要成果:
- 与对照组相比,SG患者的基线BMI较高,但OXT水平相似.
- 在12个月的时间里,SG患者的BMI,LM和FM的减少更大.
- 在SG患者手术后,血清OXT水平显著下降,并与LM减少有关,但没有FM或aBMD变化.
结论:
- 袖子胃切除术与OXT水平降低和瘦肉量显著减少有关.
- OXT通路代表了一个潜在的治疗目标,以减轻腹手术后的瘦肉质量损失.
- 需要进一步的研究来探索OXT在SG后的肌肉质量和功能维护中的作用.
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