尼古丁和骨肌肉中的微血管反应,因急性暴露于香烟和vaping
Christopher R Pitzer1, Eiman A Aboaziza2,3, Juliana M O'Reilly1
1Division of Exercise Physiology, School of Medicine, West Virginia University, Morgantown, WV 26506, USA.
International journal of molecular sciences
|June 28, 2023
概括
电子烟 (E-cigs) 对血管健康来说并不比传统香烟更安全. 电子烟在骨肌肉血管中引起类似的血管收缩反应,表明血管疾病的风险相似.
科学领域:
- 心血管科学 心血管科学
- 肺部毒理学 肺部毒理学
- 血管生理学 血管生理学
背景情况:
- 电子烟 (E-cigs) 或vaping通常被推销为传统香烟的更安全的替代品.
- 然而,新出现的证据表明,潜在的风险,特别是关于血管功能障碍和疾病.
- 电子烟使用对骨肌肉中微血管反应的影响仍然不太清楚.
研究的目的:
- 调查E-cig气溶暴露对小鼠骨肌动脉的血管和内皮功能的急性影响.
- 为了比较血管对E-cig气溶和传统香烟烟雾的反应.
- 为了确定尼古丁或其他电子液体成分是否对观察到的血管影响负责.
主要方法:
- 在麻醉后的C57Bl/6小鼠中使用了静脉内显微镜.
- 对电子烟气溶或3R4F参考卷烟烟雾进行的急性 (10抽) 暴露.
- 评估了电子液体中的单个成分 (尼古丁,植物甘油,乙烯甘醇) 对血管反应.
主要成果:
- 电子烟气溶暴露引起了类似于香烟烟雾的外周血管收缩.
- 这种血管收缩反应并不依赖于尼古丁.
- 在急性暴露模型中,内皮细胞介导的血管扩张没有改变.
- 植物甘油和烯糖醇基溶液都导致了类似的血管收缩反应.
结论:
- 吸入气溶或烟雾中的尼古丁以外的成分会触发骨肌肉中的外周血管收缩.
- 电子液体的基溶液成分 (VG/PG比) 并没有显著改变急性血管反应.
- 电子烟对血管的风险与吸食传统香烟相似,可能导致类似的不良血管健康结果.
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