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Published on: July 2, 2019

疏水性金纳米颗粒对SOPC脂质膜结构和流动性的影响

Poornima Budime Santhosh¹, Tihomir Tenev¹, Luka Šturm²

¹Institute of Solid State Physics, Bulgarian Academy of Sciences, Tzarigradsko Chaussee 72, 1784 Sofia, Bulgaria.

International journal of molecular sciences

|June 28, 2023

概括

高达2重%的疏水性金纳米颗粒 (AuNPs) 并没有改变SOPC脂质膜的结构或流动性. 这表明它们的安全性和适合于生物医学应用,如药物输送.

科学领域:

生物医学纳米技术生物医学纳米技术
脂质膜生物物理学的生物物理学
材料科学材料科学材料科学

背景情况:

黄金纳米粒子 (AuNPs) 在生物医学领域显示出潜力,包括传感器,成像和癌症治疗.
评估AuNP对脂质膜的影响对于安全性和扩展纳米医学应用至关重要.

研究的目的:

为了研究疏水性AuNP对zwitterionic1-stearoyl-2-oleoyl-sn-glycerol-3-phosphocholine (SOPC) 脂质双层的影响.
分析结构和流动性的变化,在不同的AuNP度 (0.5,1和2 wt.%) 中进行分析.

主要方法:

使用富里埃变换红外光谱法 (FTIR) 来分析分子振动.
采用光光谱学,特别是温度依赖的光异性学,以评估膜流动性.
使用传输电子显微镜进行AuNP大小 (2.2 ± 1.1 nm) 的特征.

主要成果:

FTIR显示甲拉伸带的轻微变化;碳基和基组没有受到影响.
光异质性测量表明,膜内的脂质顺序没有显著变化.
即使是2重%的AuNPs也没有引起膜结构或流动性的重大变化.

结论:

在测试度下,疏水性AuNP不会显著影响SOPC脂质双层结构或流动性.
这些发现支持使用AuNP来创建用于生物医学应用的脂质体-AuNP杂交体.
证明的生物相容性对药物输送和治疗策略具有前景.

关键词:

生物医学应用程序金纳米颗粒的金子纳米颗粒红外光谱学红外光谱学膜流动性膜流动性脂质是一种脂质.

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