血脂组学分析揭示了 Lysophosphatidylcholines 在腹腔大动脉动脉瘤进展和形成中的潜在作用
Ting Xie1, Chuxiang Lei2, Wei Song3
1Clinical Biobank, Department of Medical Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
International journal of molecular sciences
|June 28, 2023
概括
减少的溶酸胆 (lysoPCs) 与腹腔大动脉瘤 (AAA) 的发展和进展有关. 在AAA患者和小鼠中较低的lysopcc水平表明它们可能成为AAA病变发生的生物标志物.
科学领域:
- 心血管研究研究心血管研究
- 利皮多米克 (Lipidomics) 是一种消化剂.
- 动脉样硬化是一种动脉样硬化.
背景情况:
- 腹腔大动脉瘤 (AAA) 涉及大动脉扩张,脂质沉积表明脂质疾病的作用.
- 了解AAA病因中的脂质变异对于识别疾病机制至关重要.
研究的目的:
- 系统地描述与AAA大小和进展有关的脂管组学.
- 调查特定脂质在AAA病变发生过程中的作用.
主要方法:
- 从106名人类受试者 (36名对照组,70名AAA患者) 的血中进行非向性脂管学分析.
- 建立一个AAA小鼠模型 (ApoE-/-小鼠中的血管酶二) 进行连续血液采集以进行脂质组分析.
- 使用错误发现率 (FDR) < 0.05 的统计分析.
主要成果:
- Lysophosphatidylcholines (lysoPCs) 在AAA患者和小鼠中显著降低.
- 在小鼠中,较低的lysopc水平与更大的AAA直径相关,并且随着动脉瘤的进展而增加.
- 与对照组相比,在AAA患者中观察到lysopcs,HDL-c,CAD率和hsCRP之间的相关性发生变化.
结论:
- 减少的lysoPCs与腹腔大动脉动脉瘤的发病有关.
- Lysophosphatidylcholines 显示为AAA发展和进展的潜在生物标志物具有前途.
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