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在口腔癌的进展中TGF-β信号

Yuanyuan Guo^1,2, Tiansong Xu³, Yujuan Chai¹

¹Department of Biomedical Engineering, Shenzhen University Medicine School, Shenzhen University, Shenzhen 518060, China.

International journal of molecular sciences

|June 28, 2023

概括

转化生长因子β (TGF-β) 在口腔癌中具有双重作用,促进和抑制瘤. 了解TGF-β信号传递是开发新的口腔癌治疗方法的关键.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
癌症研究癌症研究

背景情况:

口腔癌是一个重要的全球健康问题,占所有恶性瘤的1.9%至3.5%.
转化生长因子β (TGF-β) 是一种关键的细胞因子,在口腔癌的发展和进展中表现出复杂而至关重要的作用.

研究的目的:

对口腔癌中TGF-β信号转导的分子机制进行审查,包括口腔状细胞癌,唾液腺体系统性癌和囊瘤的瘤.
讨论关于TGF-β的双重前瘤和瘤抑制功能的支持和矛盾证据.
评估TGF-β通路向药物在口腔癌治疗中的治疗潜力和挑战.

主要方法:

文献综述总结了TGF-β信号转导的分子机制.
对TGF-β的前瘤性活动 (例如,促进入侵,转移,免疫抑制) 的证据分析.
评估TGF-β的瘤抑制作用以及触发其独特作用的不清楚机制.

主要成果:

TGF-β信号通路与各种口腔癌类型有关,表现出促进瘤和抑制瘤的活动.
在口腔癌中TGF-β的独特作用背后的机制仍然不完全理解.
新兴的基于TGF-β通路的治疗方法在口腔癌临床试验中显示出有前途的结果.

结论:

对TGF-β信号通路的全面理解对于推进口腔癌治疗策略至关重要.
准TGF-β通路有可能改善口腔癌的治疗结果.
需要进一步的研究来阐明TGF-β的复杂作用,并优化口腔癌的途径治疗方法.

关键词:

在TGF-β信号通路中.乳头囊瘤瘤瘤瘤瘤瘤瘤这是一个机制机制.口腔癌是指口腔癌的发生.口腔状细胞癌的发生.唾液腺囊性癌瘤治疗药物治疗药物

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