关于移植后患者免疫抑制治疗的现状
Kamila Szumilas1, Aleksandra Wilk2, Piotr Wiśniewski3
1Department of Physiology, Pomeranian Medical University in Szczecin, 70-111 Szczecin, Poland.
International journal of molecular sciences
|June 28, 2023
概括
接受移植的人需要免疫抑制药物来防止器官排斥. 本综述详细介绍了各种免疫抑制疗法,它们的机制和相关并发症,以改善患者的治疗结果.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 免疫学 免疫学 免疫学
- 药理学 药理学 是一个学科.
背景情况:
- 移植是对末期功能衰竭的最佳治疗方法.
- 免疫抑制疗法对于预防器官排斥和延长移植存活至关重要.
- 药物选择取决于诸如移植后的时间,疾病病因和移植条件等因素.
研究的目的:
- 审查用于移植的免疫抑制药物类别.
- 描述它们在诱导和维持疗法中的作用机制.
- 讨论免疫系统调节和与这些药物相关的并发症.
主要方法:
- 在移植中使用免疫抑制药物的文献综述.
- 基于治疗阶段 (诱导/维持) 的药物的分类.
- 对药物机制,疗效和副作用的分析.
主要成果:
- 标准三重药物治疗的概述 (氨酸抑制剂,皮质类固醇,抗增殖剂).
- 讨论药物类别,作用方式和免疫调节.
- 描述并发症和替代性免疫抑制策略.
结论:
- 个性化免疫抑制治疗对于接受移植的人来说至关重要.
- 目前正在进行的研究旨在开发更安全,更有效的免疫抑制剂.
- 尽量减少毒性和副作用可以改善长期的移植功能和患者的存活率.
相关概念视频
Kidney Transplant III: Nursing Management
41
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
41
Kidney Transplant II: Surgical Procedure
36
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
36
Kidney Transplant I: Introduction
29
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
29
Acute Kidney Injury III: Clinical Manifestations
44
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
44
Nephrotic Syndrome III : Nursing Management
20
Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
20
Acute Kidney Injury IV: Diagnostic Studies and Prevention
40
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
40


