维生素D和维生素D结合蛋白在健康和疾病中 2.0
Charlotte Delrue1, Marijn M Speeckaert1,2
1Department of Nephrology, Ghent University Hospital, 9000 Ghent, Belgium.
International journal of molecular sciences
|June 28, 2023
概括
维生素D,阳光营养素,在整体健康和疾病预防方面发挥着至关重要的作用. 了解它的功能是保持健康和管理各种健康状况的关键.
科学领域:
- 营养科学 营养科学
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 维生素D,或"阳光营养素",是一种重要的脂肪溶性二类固醇. 它的作用超越了骨健康,影响了许多生理过程. 新兴研究强调了它对健康和疾病的广泛影响.
- 在UVB暴露时皮肤中合成维生素D是主要的来源,饮食摄入量和补充剂也为此做出了重大贡献. 诸如度,季节,皮肤颜色和防晒使用等因素会影响维生素D水平.
- 缺乏症在全球普遍存在,与各种慢性疾病有关,包括骨质疏松症,自身免疫性疾病,心血管疾病和某些癌症. 这强调了维持适当的维生素D状态的重要性.
研究的目的:
- 探索维生素D对健康的各种影响.
- 审查目前对维生素D在预防和管理疾病中的作用的理解.
- 突出维护公共健康最佳维生素D水平的重要性.
主要方法:
- 关于维生素D的现有研究的综合文献综述.
- 流行病学数据和临床试验结果的分析.
- 关于维生素D功能的当前科学共识的综合.
主要成果:
- 维生素D对于的吸收和骨代谢至关重要,可以预防恶心病和骨质疏松症.
- 适当的维生素D水平与老年人骨质疏松症,跌倒和骨折的风险降低有关.
- 新兴证据表明,维生素D参与免疫功能,炎症调节和细胞过程,可能影响自身免疫性疾病,感染和癌症风险.
- 观察性研究将低维生素D状态与心血管疾病,糖尿病和神经退行性疾病的风险增加联系起来,尽管因果关系需要进一步调查.
- 补充试验显示混合结果,取决于人口,剂量和测量结果,需要个性化方法.
结论:
- 维生素D对骨健康至关重要,并在许多骨外功能中发挥重要作用,包括免疫调节和慢性疾病预防.
- 通过阳光照射,饮食或补充剂维持足够的维生素D水平对于整体健康和疾病管理至关重要.
- 需要进一步的研究来阐明维生素D在各种健康状况中的具体机制,最佳水平和治疗应用.
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