相关实验视频
Updated: Jul 25, 2025

09:18
A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
Published on: July 28, 2023
2.7K
肠道微生物群和神经系统之间的交叉:微生物和代谢体之间的双向相互作用
Monica Montagnani1, Lucrezia Bottalico2, Maria Assunta Potenza1
1Department of Precision and Regenerative Medicine and Ionian Area-Section of Pharmacology, School of Medicine, University of Bari "Aldo Moro", Policlinico University Hospital of Bari, Piazza G. Cesare 11, 70124 Bari, Italy.
International journal of molecular sciences
|June 28, 2023
概括
肠道微生物群影响行为和中枢神经系统 (CNS) 活动. 研究正在探索肠-大脑轴,以了解肠道失调和中枢神经系统疾病之间的联系.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 肠道微生物群影响行为和免疫反应,可能反映抑郁和焦虑的症状.
- 中枢神经系统 (CNS) 和肠道微生物群通过各种机制共享连接,尽管直接与中枢神经系统病理和肠道失生症的流行病学联系需要进一步研究.
- 肠道神经系统 (ENS) 是外周神经系统中的一个复杂的神经网络,具有独立的功能并与中枢神经系统通信.
研究的目的:
- 探索肠道微生物群/大脑轴的功能作用和生理病理影响.
- 研究肠道微生物,新陈代谢和中枢神经系统神经和精神病理疾病的发生之间的联系.
主要方法:
- 审查有关肠道微生物群,行为和中枢神经系统活动的现有研究.
- 分析将肠道微生物群与中枢神经系统联系起来的机制.
- 探索肠道神经系统在肠-大脑轴中的作用.
主要成果:
- 肠道微生物群显著影响行为和免疫系统的变化.
- 肠道微生物群的组成和功能似乎影响中枢神经系统的活动.
- 肠神经系统在肠-大脑沟通中起着至关重要的作用.
结论:
- 肠道微生物群/大脑轴是理解神经和精神疾病的重要研究领域.
- 需要进一步调查,以确定明确的流行病学证据,将中枢神经系统病理与肠道失生症联系起来.
- 肠道微生物,新陈代谢和神经系统之间的相互作用在神经退行,自身免疫性疾病,抑郁,焦虑和自闭症等疾病中至关重要.
相关概念视频
Physiology of Enteric Nervous System and Gut Health
329
The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
329
Enteric Nervous System: Regulation of GI Motor Activity
488
The Enteric Nervous System (ENS) plays a pivotal role in regulating gastrointestinal or GI motor activity. This complex network of nerves, deeply embedded within the gut wall, responds to changes in the gut environment and receives input from both the autonomic nervous system and the central nervous system. By doing so, the ENS operates various programs tailored to the body's nutritional status and needs.
During periods of fasting, the ENS initiates the migrating myoelectric complex, a...
During periods of fasting, the ENS initiates the migrating myoelectric complex, a...
488
Neural Regulation
39.6K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.6K
Nerve Supply of the GI Tract
1.5K
The neuronal supply to the gastrointestinal (GI) tract is essential for regulating various functions, including digestion, absorption, and movement of food. This intricate network of nerves is known as the enteric nervous system (ENS), often referred to as the "second brain" of the body.
The enteric nervous system consists of two major plexuses: the myenteric plexus (Auerbach's plexus) and the submucosal plexus (Meissner's plexus). These plexuses are located within the layers of...
The enteric nervous system consists of two major plexuses: the myenteric plexus (Auerbach's plexus) and the submucosal plexus (Meissner's plexus). These plexuses are located within the layers of...
1.5K
Irritable Bowel Syndrome I: Introduction
325
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
325
Disorders of the Nervous Tissue
1.4K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
1.4K

