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专是人类血液等离子体雌激酶状态的一个组成部分

Daria A Belinskaia¹, Polina A Voronina¹, Polina I Popova²

¹Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, pr. Torez 44, 194223 St. Petersburg, Russia.

International journal of molecular sciences

|June 28, 2023

概括

血雌激酶状态,包括人血清白蛋白 (HSA) 活性,在COVID-19患者中显示出显著的差异. 一个涉及尿素,MDA和白蛋白的新型指数可以预测疾病的严重程度.

科学领域:

生物化学生物化学
临床化学临床化学
病理生理学病理生理学

背景情况:

血雌激酶状态是各种疾病的普遍标志物.
血清白蛋白的雌激酶活性对于理解血雌激酶状态至关重要.
COVID-19的严重程度可能与雌激酶活性和白蛋白水平的变化有关.

研究的目的:

为了研究COVID-19患者血的雌激酶状态.
评估酶状态 (包括人血清白蛋白 - HSA) 和其他生化参数之间的关系.
为了比较这些标记物在幸存和已故的COVID-19患者和健康个体之间.

主要方法:

在体外和in silico实验中研究HSA酶活性与各种基质和抑制剂.
在健康受试者和COVID-19患者 (幸存者与死者) 中对血雌激酶状态和生化指数进行比较分析.

主要成果:

在健康和COVID-19患者之间,以及在幸存者和已故患者之间,在酶状态和生物化学指数 (包括白蛋白) 中观察到有统计学意义的差异.
专蛋白进一步被验证为重要的诊断标记物.
新型指数 ([尿素] × [MDA] × 1000/[BChEb × [ALB]) 在已故患者中明显高于幸存者和健康对照人群.

结论:

血雌激酶状态,特别是涉及HSA,在COVID-19中发生显著变化,与疾病严重程度相关.
新型指数显示了作为COVID-19死亡率预测标志物的潜力.
对酶活性和白蛋白在传染病中的作用进行进一步的研究是有必要的.

关键词:

在 COVID-19 疫情中,专辑蛋白 (albumin) 是一种生物标志物生物标志物碳酸乙酶 (carboxylesterase) 是一种胆化酶是一种胆化酶.诊断诊断诊断诊断诊断化酶的状态

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