细胞癌瘤微环境中的细胞和分子参与者
Francesco Lasorsa1, Monica Rutigliano1, Martina Milella1
1Urology, Andrology and Kidney Transplantation Unit, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari "Aldo Moro", 70124 Bari, Italy.
Journal of clinical medicine
|June 28, 2023
概括
清细胞细胞癌 (ccRCC) 是一种常见的癌. 了解瘤微环境 (TME) 是改善免疫疗法和降低晚期ccRCC治疗耐药性的关键.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 癌症生物学 癌症生物学
背景情况:
- 清细胞细胞癌 (ccRCC) 是全球最常见的癌.
- 转移性疾病和手术后复发是ccRCC管理的重大挑战.
- 先进的ccRCC治疗包括铁激酶抑制剂 (TKI) 和免疫检查点抑制剂 (ICI).
研究的目的:
- 在ccRCC中研究瘤微环境 (TME) 内的复杂相互作用.
- 阐明TME在免疫逃生机制中的作用.
- 在TME中确定潜在的治疗点,以提高免疫治疗的疗效和克服耐药性.
主要方法:
- 审查关于ccRCC,TME组成和免疫相互作用的当前文献.
- 分析与TME特征 (如pH,营养竞争) 相关的免疫逃逸机制.
- 探索TME内的癌细胞,免疫细胞和细胞外基质 (ECM) 之间的相互作用.
主要成果:
- TME包括癌细胞,非恶性细胞和改变的ECM,影响癌症的进展.
- 在TME中的因素,如酸度和营养竞争,有助于免疫逃避.
- 癌细胞和TME组件之间的相互作用对于癌症的发展和治疗反应至关重要.
结论:
- 对ccRCC瘤微环境动态的全面了解至关重要.
- 针对TME组件及其相互作用提供了增强免疫疗法的有希望的策略.
- 对ccRCC TME内的免疫细胞功能和相互作用的进一步研究对于开发更有效的治疗方法至关重要.
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