在COVID-19患者中与炎症生物标志物和临床结果相关的旋转血小板造影 (ROTEM®)
Pawel Rogalski1, Magdalena Rogalska2, Diana Martonik2
1Department of Gastroenterology and Internal Medicine, Medical University of Bialystok, 15-276 Białystok, Poland.
Journal of clinical medicine
|June 28, 2023
概括
旋转血小板造影仪 (ROTEM®) 显示了COVID-19患者的高凝血能力. 提升的FIBTEM最大凝块弹性 (MCE) 强烈预测了糟糕的结果,这表明它在评估COVID-19严重性的有用性.
科学领域:
- 凝血和血栓形成的原因
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
背景情况:
- COVID-19的致病性涉及复杂的高凝性,尚未完全理解.
- 旋转血栓弹性测量 (ROTEM®) 使用粘弹性方法评估静脉血样.
- 炎症性细胞因子概况与COVID-19相关的凝血病有关.
研究的目的:
- 在COVID-19患者中调查ROTEM®参数和炎症性细胞因子之间的关系.
- 为了将ROTEM®发现与临床结果和疾病严重程度相关联.
- 评估不同ROTEM®测试在COVID-19中高凝血性的诊断价值.
主要方法:
- 63名参与者的前性研究 (29名COVID-19患者,34名对照).
- 评估ROTEM®测试 (NATEM®,EXTEM®,FIBTEM®) 和炎症标志物 (CRP,IL-8,IL-1β,IL-6,IL-10,TNF,IL-12p70) 的使用情况.
- 分析ROTEM®参数,细胞因子水平,CT严重程度得分和临床结果之间的相关性.
主要成果:
- 在所有测试中,ROTEM®在COVID-19患者中始终显示出高凝血能力.
- 在COVID-19患者中,所有测量的炎症性细胞因子水平显著提高.
- FIBTEM参数与炎症生物标志物和CT严重程度得分的相关性最强.
- 较高的FIBTEM最大凝块弹性 (MCE) 是不良结果的最强预测因素.
结论:
- 增加的FIBTEM MCE与更大的COVID-19严重程度有关.
- 在检测COVID-19高凝血性方面,非激活的ROTEM (NATEM) 似乎比激活的ROTEM (EXTEM) 更有效.
- ROTEM®参数,特别是FIBTEM MCE,为COVID-19凝血病和预后提供了宝贵的见解.
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