贝纳利祖马布在严重的乙酸性喘中有效性与支气管切除症的同时存在:一个真实世界的多中心观察研究
Raffaele Campisi1, Santi Nolasco1,2, Corrado Pelaia3
1Respiratory Medicine Unit, Policlinico "G. Rodolico-San Marco" University Hospital, 95123 Catania, Italy.
Journal of clinical medicine
|June 28, 2023
概括
贝纳利祖马布有效治疗严重的酸性喘 (SEA),改善恶化和肺功能. 然而,同时存在支气管切除症 (BE) 的患者体验到的益处较少,包括减少口服皮质类固醇使用.
科学领域:
- 肺部病理学 肺部病理学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 严重的酸性喘 (SEA) 经常与支气管切除症 (BE) 共同存在.
- 关于本拉利祖马布在SEA患者同时发生BE (SEA + BE) 的疗效的数据有限.
- 根据BE的严重程度评估治疗反应至关重要.
研究的目的:
- 评估本拉利祖马布在SEA患者中的疗效.
- 为了比较SEA患者与没有BE (SEA + BE) 之间的治疗结果.
- 分析BE严重程度对治疗有效性的影响.
主要方法:
- 在74名SEA患者的多中心观察研究中,这些患者接受了本拉利祖马布治疗.
- 胸部高分辨率计算机断层扫描 (HRCT) 用于支气管切除症评估.
- 支气管切除症严重程度指数 (BSI) 用于量化BE严重程度.
- 在基线和12个月后收集的临床和功能数据.
主要成果:
- 本拉利祖马布显著降低了恶化率,口服皮质类固醇 (OCS) 消费,并改善了整体肺功能.
- 与SEA单独相比,SEA+BE患者的无恶化期 (20% vs. 64.1%) 和OCS戒断率 (-48.6% vs. -92.6%) 与SEA单独相比显著降低.
- 缓解率 (零恶化和零OCS) 在SEA + BE组 (14.3%与66.7%) 显著较低.
- 肺功能恶化 (FEV1%,FEF25-75%) 与较高的BSI得分相关.
结论:
- 贝纳利祖马布对有或没有支气管切除症的SEA患者显示出好处.
- 同时存在支气管切除症 (SEA + BE) 的患者获得了较少的OCS节省和呼吸功能较小的改善.
- 用BSI表示的BE严重程度会对SEA患者的本拉利祖马布治疗结果产生负面影响.
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