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增强疗法作为治疗共存的精神分裂症的体质问题-一个系统性审查
Wiktor Dróżdż1, Michał Wiciński2, Anna Maria Szota1
1Department of Psychiatry, Ludwig Rydygier Collegium Medicum in Bydgoszcz of Nicolaus Copernicus University in Toruń, Curie Skłodowskiej Street 9, 85-094 Bydgoszcz, Poland.
Journal of clinical medicine
|June 28, 2023
概括
用阿司匹林或西姆瓦斯塔丁等药物增加抗精神病治疗可能会减少精神分裂症症状. 需要进一步的长期研究来证实这些发现用于精神分裂症治疗.
科学领域:
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
背景情况:
- 精神分裂症的治疗通常涉及抗精神病药物.
- 解决残留症状和体质投诉仍然是精神分裂症管理中的一个挑战.
- 探索辅助疗法可能会提高治疗疗效.
研究的目的:
- 对结合抗精神病药物与非抗精神病药物的随机临床试验 (RCT) 进行审查.
- 评估增强策略在管理精神分裂症症状中的有效性.
- 为了确定增强抗精神病治疗的非抗精神病药物.
主要方法:
- 在PubMed数据库进行系统搜索,截至2022年2月.
- 包括成人慢性精神分裂症增强疗法与心理测量评估的RCT.
- 排除对第一发精神分裂症或非辅助治疗的研究.
主要成果:
- 选择了37项涉及1931名患者的研究.
- 观察到积极和消极精神分裂症症状 (PANSS尺度) 的显著减少.
- 有效的组合包括抗精神病药物与阿司匹林,西姆瓦斯塔丁,N-乙半氨酸或皮奥格利塔.
结论:
- 结合治疗与特定的非抗精神病药物显示出减轻精神分裂症症状的前景.
- 作为增强剂的阿司匹林,simvastatin,N-乙半氨酸和pioglitazone需要进一步调查.
- 需要长期研究来验证这些增强策略的持续有效性和安全性.
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