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肥胖作为COVID-19严重结果的危险因素:一对匹配的1:2病例控制研究
Antonio Russo1, Mariantonietta Pisaturo1, Verdiana Zollo1
1Infectious Diseases Unit, Department of Mental Health and Public Medicine, University of Campania "L. Vanvitelli", 80138 Napoli, Italy.
肥胖与严重的COVID-19结果有关,包括更高的重症监护需求和死亡率. 建议对患有SARS-CoV-2感染的肥胖患者 (BMI ≥30 kg/m2) 进行早期抗病毒治疗,以防止严重的疾病进展.
科学领域:
- 传染性疾病 传染性疾病
- 代谢障碍 代谢障碍 代谢障碍
- 临床医学 临床医学
背景情况:
- 肥胖和COVID-19预后之间的关联需要进一步澄清,特别是在考虑其他并发病时.
- 肥胖是一种普遍的疾病,已知对免疫反应和疾病严重性的影响.
研究的目的:
- 通过肥胖状况分层研究SARS-CoV-2感染患者的临床结果.
- 为了比较疾病严重程度,重症监护室 (ICU) 入院率和肥胖和非肥胖COVID-19患者之间的死亡率.
主要方法:
- 采用了一种对应的病例控制研究设计.
- 病例包括患有SARS-CoV-2感染的住院成年人和体重指数 (BMI) ≥30 kg/m2.
- 对照组由两名非肥胖 (BMI <30 kg/m2) 患者组成,他们的性别,年龄,并发症数量和查尔森并发症指数相匹配.
主要成果:
- 肥胖患者需要重症监护治疗的可能性显著增加 (41.8%与26.6%,p = 0.001).
- 住院期间死亡的发生率在肥胖组中较高 (12.1%对6.4%,p = 0.046).
- 非肥胖患者更频繁地发展出轻度至中度疾病 (67%vs46.1%).
结论:
- 肥胖独立地与COVID-19患者的严重结局有关.
- 患有BMI≥30kg/m2且感染SARS-CoV-2的个体,应及早对抗病毒治疗进行评估.
- 积极管理可以减轻肥胖COVID-19患者严重疾病进展的风险.
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