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Updated: Jul 25, 2025

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评估与COVID-19患者呼吸衰竭相关的幽默免疫炎症途径
Matteo Regolo1,2, Alessandra Sorce3, Mauro Vaccaro4
1Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.
Journal of clinical medicine
|June 28, 2023
概括
中性粒细胞与淋巴细胞的比率 (NLR) 预测了严重的COVID-19患者的死亡率,而C反应蛋白 (CRP) 则表明了重症监护室 (ICU) 的入院. 这些炎症标志物与疾病的严重程度和结果相关.
科学领域:
- 关键护理医学 关键护理医学
- 传染性疾病 传染性疾病
- 临床病理学 临床病理学
背景情况:
- 严重的COVID-19病例有可能发展为急性呼吸困扰综合征 (ARDS).
- 在COVID-19患者的呼吸道症状可能不准确地反映疾病恶化.
- 了解炎症标志物对于预测严重的COVID-19结果至关重要.
研究的目的:
- 在严重的COVID-19患者中调查中性粒细胞与淋巴细胞比率 (NLR) 和C反应蛋白 (CRP) 的异步趋势.
- 评估NLR和CRP对死亡率和重症监护病房 (ICU) 入院的预测价值.
- 为了确定NLR,CRP和PaO2/FiO2 (P/F) 比率之间的关系.
主要方法:
- 来自意大利两家医院的764名严重COVID-19患者的回顾性分析.
- 在整个住院期间监测NLR和CRP趋势.
- 统计分析以评估NLR和CRP与死亡率,ICU入院和P/F比率的关联.
主要成果:
- 在死亡患者中,NLR显示出日益增长的趋势,预测死亡率 (HR: 1.77).
- 在ICU入院患者中,CRP水平最初下降,但在住院结束时急剧增加,预测ICU入院 (HR:1.70).
- 年龄,中性粒细胞,CRP和淋巴细胞与P/F比率直接相关,中性粒细胞调解CRP的影响.
结论:
- 对于COVID-19的严重程度,NLR和CRP表现出不同的趋势和预测值.
- NLR是死亡率的重要预测因素,而CRP与ICU入院有关.
- 炎症标志物,特别是中性粒细胞和CRP,在严重的COVID-19的呼吸损害 (P/F比率) 中起着关键作用.
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