急性损伤中的代谢学:临床视角
Daniel Patschan1,2, Susann Patschan1,2, Igor Matyukhin1,2
1Department of Medicine 1, Cardiology, Angiology, Nephrology, Brandenburg Medical School Theodor Fontane, University Hospital Brandenburg, 14770 Brandenburg, Germany.
Journal of clinical medicine
|June 28, 2023
概括
代谢学在诊断急性损伤 (AKI) 和预测患者结果方面表现有前途. 然而,目前使用代谢学来预测AKI风险的研究是有限的,这凸显了需要进一步调查的需要.
科学领域:
- 生物化学 生物化学
- 临床医学 临床医学
- 基因组学就是基因组学.
背景情况:
- 急性损伤 (AKI) 是一个日益严重的全球健康问题,由于依赖血清肌素,往往被诊断为晚期.
- 现有的AKI生物标志物在可靠性方面还没有超过血清肌素.
- 代谢学提供了一种全面的方法来检测和量化生物样本中的众多代谢物.
研究的目的:
- 总结研究代谢药在诊断急性损伤 (AKI) 中的作用的临床研究.
- 审查代谢学在预测AKI风险和患者结果方面的应用.
- 确定AKI研究中的代谢学目前的局限性和未来方向.
主要方法:
- 从1940年到2022年,在PubMed,科学网,科克兰图书馆和Scopus进行了系统的文献搜索.
- 搜索术语包括"AKI"",代谢学"的变化,以及相关的结果预测因素,如"风险"",死亡"",生存"和"置换疗法".
- 如果这些研究使用代谢分析来诊断或预测AKI风险,那么这些研究就被选中了,但不包括动物研究.
主要成果:
- 八项研究符合纳入标准,其中六项专注于AKI诊断,两项专注于AKI风险预测.
- 代谢学已经成功地确定了AKI诊断的潜在新生物标志物.
- 关于使用代谢学来预测AKI风险 (例如死亡,需要置换疗法或功能恢复) 的数据仍然很少.
结论:
- AKI的复杂性和多样性需要综合方法,包括代谢学和其他"omics"技术.
- 进一步的研究至关重要,以充分利用代谢学来改善AKI患者的临床结果.
- 代谢学有可能促进急性损伤的诊断和预后.
相关概念视频
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