电心电图在发作后期的变化:从前性研究的结果
Lorenzo Gigli1, Simone Sala2, Alberto Preda2
1De Gasperis Cardiocenter, Electrophisiology Unit, Niguarda Hospital, 20162 Milan, Italy.
Journal of clinical medicine
|June 28, 2023
概括
在发作后的心电图 (ECG) 异常可能会揭示隐藏的心肌管道病变. 冲击后心电图对于诊断像布鲁加达模式 (BEP) 这样的疾病至关重要,患者有突然死亡的高风险.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 遗传学 遗传学 是一个
背景情况:
- 大脑和心脏共享生理路径,导致患者心电图异常的患病率更高.
- ,遗传性心律失常和突然死亡已知是相互关联的.
- 和心肌管道病变之间的联系需要进一步调查.
研究的目的:
- 调查12导电心电图 (ECG) 在发作后进行的诊断作用.
- 评估患者心脏通道病变的患病率.
主要方法:
- 对117名因而入院的患者进行前性观察性研究.
- 收集神经学,心脏学和心电图数据,包括心电图后和基础心电图.
- 使用下一代测序 (NGS) 对患有异常后冲击心电图的患者.
主要成果:
- 52名患者有异常的冲击后心电图;28名患者有异常的基础心电图.
- 在8名患者中发现了布鲁加达心电图 (BEP) 图案,其患病率比一般人群高10:1.
- 对三名心肌管道病变的病原性基因变异在三个患有冲击后心电图变化的患者中被确定.
结论:
- 冲击后心电图可以揭示患者可能隐藏的心脏异常.
- 布鲁加达心电图图案 (BEP) 的发生率在经历夜间的患者中较高.
- 发作后的心电图评估对于识别风险人群中的通道病变是有价值的.
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