获得的XIII因子缺乏症在ECMO治疗期间很常见,并与重大出血事件和输血需求有关
Matthias Noitz1, Roxane Brooks1, Johannes Szasz1
1Department of Anesthesiology and Intensive Care Medicine, Kepler University Hospital GmbH, Johannes Kepler University Linz, Krankenhausstraße 9, 4020 Linz and Altenberger Strasse 69, 4040 Linz, Austria.
Journal of clinical medicine
|June 28, 2023
概括
在接受体外膜氧化疗法 (ECMO) 的成年人中,获得的XIII因子缺乏症很常见. 这种缺陷显著增加了在ECMO期间出现严重出血和输血需求的风险.
科学领域:
- 关键护理医学 关键护理医学
- 血液学 血液学 血液学
- 心血管研究研究心血管研究
背景情况:
- 在接受体外膜氧化 (ECMO) 治疗的患者中,出血并发症是一个重大问题.
- 了解出血的根本原因对于改善患者的治疗结果至关重要.
研究的目的:
- 调查成年ECMO患者中获得的XIII因子缺乏症的发生率.
- 为了确定XIII因子缺乏和重大出血事件之间的关联.
- 评估因子XIII缺乏对ECMO期间输血需求的影响.
主要方法:
- 追溯的单中心队列研究分析了成年患者在静脉或静脉动脉ECMO在2年的时间.
- 测量了XIII因子的活性,并通过ECMO期间记录的最低活性来定义缺陷.
- 使用统计分析,包括多变量回归来评估关联.
主要成果:
- 在分析的84名ECMO患者中,69%的ECMO患者发现了XIII因子缺乏.
- 患有XIII因子缺乏症的患者经历的重大出血事件显著增加 (OR,3.37;p = 0.02).
- 在XIII因子缺乏的患者中,观察到红细胞和血小板的输血需求更高.
结论:
- 成人ECMO患者中获得的XIII因子缺乏症非常普遍,影响了近70%的个体.
- 十三因子缺乏是ECMO患者出血严重程度增加和输血需求的独立风险因素.
- 这凸显了监测和潜在地管理ECMO患者的XIII因子活性的重要性,以减轻出血风险.
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